Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide
文献类型：期刊论文
| 作者 | Wang, SG; Hou, JW; Bei, JZ; Zhao, YQ |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2001-08-01 |
| 卷号 | 44期号:4页码:419-426 |
| 关键词 | Nerve Conduit Nerve Guiding Regeneration Biodegradation Biocompatibility Tissue Engineering Poly(d L-lactide) |
| ISSN号 | 1006-9291 |
| 英文摘要 | The biodegradation rate and biocompatibility of poly(d, l-lactide) (PDLLA) in vivo were evaluated. The aim of this study was to establish a nerve guide constructed by the PDLLA with 3-D microenvironment and to repair a 10 mm of sciatic nerve gap in rats. The process of the nerve regeneration was investigated by histological assessment, electrophysiological examination, and determination of wet weight recovery rate of the gastrocnemius muscle. After 3 weeks, the nerve guide had changed from a transparent to an opaque status. The conduit was degraded and absorbed partly and had lost their strength with breakage at the 9th week of postoperation. At the conclusion of 12 weeks, proximal and distal end of nerves were anastomosed by nerve regeneration and the conduit vanished completely. The results suggest that PDLLA conduits may serve for peripheral nerve regeneration and PDLLA is a sort of hopeful candidate for tissue engineering. |
| 语种 | 英语 |
| WOS记录号 | WOS:000171890600011 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/78043]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Peoples Hosp Henan Prov, Zhengzhou 450003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, SG,Hou, JW,Bei, JZ,et al. Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2001,44(4):419-426. |
| APA | Wang, SG,Hou, JW,Bei, JZ,&Zhao, YQ.(2001).Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide.SCIENCE IN CHINA SERIES B-CHEMISTRY,44(4),419-426. |
| MLA | Wang, SG,et al."Tissue engineering and peripheral nerve regeneration (III) - Sciatic nerve regeneration with PDLLA nerve guide".SCIENCE IN CHINA SERIES B-CHEMISTRY 44.4(2001):419-426. |
入库方式： OAI收割
来源：化学研究所
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