Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography
文献类型：期刊论文
| 作者 | Yang, GL; Li, ZW; Wang, DX; Zhang, ZF; Liu, ED; Chen, Y |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2002-10-01 |
| 卷号 | 56期号:7-8页码:515-518 |
| 关键词 | Column Liquid Chromatography Chiral Separation N-(Trans-4-isopropylcyclohexylcarbonyl)-d L-phenylalanine Isomers |
| ISSN号 | 0009-5893 |
| 英文摘要 | A high-performance liquid chromatographic method was developed for the chiral separation of a new anti-diabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, and its L-enantiomer. The separation was performed on a Sumichiral OA-3300 column. Optimized mobile phase was 0.025 mol.L-1 ammonium acetate in methanol solution. UV detection was at 210 nm. Baseline chiral separation was obtained within 12 minutes. The detection limits are 80 pg for the D-enantiomer and 120 pg for the L-enantiomer. RSD of the method was below 1% (n = 5). |
| 语种 | 英语 |
| WOS记录号 | WOS:000178836600019 |
| 出版者 | VIEWEG |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/78421]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, GL |
| 作者单位 | 1.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China 2.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, GL,Li, ZW,Wang, DX,et al. Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography[J]. CHROMATOGRAPHIA,2002,56(7-8):515-518. |
| APA | Yang, GL,Li, ZW,Wang, DX,Zhang, ZF,Liu, ED,&Chen, Y.(2002).Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography.CHROMATOGRAPHIA,56(7-8),515-518. |
| MLA | Yang, GL,et al."Chiral separation of N-(trans-4-isopropylcyclohexylcarbonyl)-D, L-phenylalanine isomers by high performance liquid chromatography".CHROMATOGRAPHIA 56.7-8(2002):515-518. |
入库方式： OAI收割
来源：化学研究所
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