Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone
文献类型：期刊论文
| 作者 | Cai, Q; Bei, JZ; Wang, SG |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2002-02-01 |
| 卷号 | 13期号:2页码:105-111 |
| 关键词 | Poly(Lactide-co-glycolide-co-caprolactone) (R-pglc) Poly(Lactide-co-glycolide) (Plga) Drug Release Behavior Degradation Morphology |
| ISSN号 | 1042-7147 |
| 英文摘要 | A series of copolylactones was synthesized by ring-opening copolymerization of glycolide, L-lactide and epsilon-caprolactone, using stannous octoate as catalyst. The in vitro degradation behaviors of them were studied and data demonstrated different degradation rates which mainly depended on the compositions. Investigation of the 5-fluorouracil (5-Fu) release from these copolylactones revealed that the composition, degradation rate and the morphology of the polymeric matrix played an important role on the drug release kinetics. A sustained 5-Fu release without initial time lag was obtained from random poly(lactide-co-glycolide-co-caprolactone) (r-PGLC) drug carrier, and it differed from the cases of polylactide (PLA) or random poly(lactide-co-glycolide) (PLGA), which usually showed an initial time lag or biphasic drug release behavior. It was due to the low, glass transition temperature (T-g) of the r-PGLC and the drug would diffuse faster in rubbery state under the experimental temperature. Furthermore, a significant change in the drug release behavior of r-PGLC was observed when the temperatures were changed around the T-g of the drug carrier, which implied that the drug release behavior could be regulated by adjusting the morphology of the drug carrier. Copyright (C) 2002 John Wiley Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000173655700004 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/78853]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Q,Bei, JZ,Wang, SG. Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2002,13(2):105-111. |
| APA | Cai, Q,Bei, JZ,&Wang, SG.(2002).Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone.POLYMERS FOR ADVANCED TECHNOLOGIES,13(2),105-111. |
| MLA | Cai, Q,et al."Relationship among drug delivery behavior, degradation behavior and morphology of copolylactones derived from glycolide, L-lactide and epsilon-caprolactone".POLYMERS FOR ADVANCED TECHNOLOGIES 13.2(2002):105-111. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。