Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid)
文献类型：期刊论文
| 作者 | Shi, GX; Cai, Q; Wang, CY; Lu, N; Wang, SG; Bei, JZ |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2002-03-01 |
| 卷号 | 13期号:3-4页码:227-232 |
| 关键词 | Poly(L-lactic Acid) Poly(L-lactic-co-glycolic Acid) Biocompatibility Porous Cell Scaffold Cell Culture |
| ISSN号 | 1042-7147 |
| DOI | 10.1002/pat.178 |
| 英文摘要 | In this paper, poly(L-lactic acid) (PLLA) and poly(L-lactic-co-glycolic acid) (PLGA) were synthesized, and the biocompatibility of PLGA(50/50) (molar ratio) was evaluated by observing the tissue response during implanting PLGA(50/50) into rats. After the PLGA(50/50) was implanted into rats for 12 weeks, the lymphocytes and plasma cells became small or disappeared at the muscle tissue of implant site which indicates the biocompatibility of PLGA(50/50) is very good. A series of porous cell scaffolds of PLGA and PLLA were prepared by using a solution-casting/salt-leaching, technique. An improved method in which a density bottle instead of a graduated cylinder was developed to measure their porosities. It was found that the accuracy and reproducibility of the improved method for measuring porosity are excellent. A porous PLGA(50/50) scaffold alas used to study chondrocytes culture. The chondrocytes were proliferated in porous PLGA(50/50) scaffold and the composite cell/PLGA was successfully obtained for cartilage regeneration. Copyright (C) 2002 John Wiley Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000174200300013 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/78925]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bei, JZ |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China 3.China PLA Gen Hosp, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, GX,Cai, Q,Wang, CY,et al. Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid)[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2002,13(3-4):227-232. |
| APA | Shi, GX,Cai, Q,Wang, CY,Lu, N,Wang, SG,&Bei, JZ.(2002).Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid).POLYMERS FOR ADVANCED TECHNOLOGIES,13(3-4),227-232. |
| MLA | Shi, GX,et al."Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid)".POLYMERS FOR ADVANCED TECHNOLOGIES 13.3-4(2002):227-232. |
入库方式： OAI收割
来源：化学研究所
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