Prediction on amphiphilicity of hypocrellin derivatives
文献类型：期刊论文
| 作者 | Xie, J; Ma, JH; Zhao, JQ |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2002-06-01 |
| 卷号 | 45期号:3页码:251-256 |
| 关键词 | Hypocrellin Derivative Prediction Of Molecular Amphiphilicity |
| ISSN号 | 1006-9291 |
| 英文摘要 | Hypocrellins are most suitable for photodynamic therapy (PDT) of the diseases occurring in the superficial layer, such as microvascular diseases, because of their special absorption spectral properties. However, hypocrellins and most of their derivatives are basically lipophilic, while the hydrophilic derivatives lose the PDT activity in vivo. Therefore, the key problem for practical application of PDT of microvascular diseases focuses on finding the derivatives which possess optimized amphiphilicity. Herein, we developed a theoretical method to estimate the amphiphilicity of a molecule by the calculated average polarity. Compared with the experimentally measured results, the method is proved to be applicable. Based on the computation and available experimental results, it can be concluded that the derivative must have the polarities around 0.22 for optimized amphiphilicity. |
| 语种 | 英语 |
| WOS记录号 | WOS:000175701300004 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/78975]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, JQ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, J,Ma, JH,Zhao, JQ. Prediction on amphiphilicity of hypocrellin derivatives[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2002,45(3):251-256. |
| APA | Xie, J,Ma, JH,&Zhao, JQ.(2002).Prediction on amphiphilicity of hypocrellin derivatives.SCIENCE IN CHINA SERIES B-CHEMISTRY,45(3),251-256. |
| MLA | Xie, J,et al."Prediction on amphiphilicity of hypocrellin derivatives".SCIENCE IN CHINA SERIES B-CHEMISTRY 45.3(2002):251-256. |
入库方式： OAI收割
来源：化学研究所
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