Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen
文献类型：期刊论文
| 作者 | Wang, MX; Zhao, SM |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2002-09-09 |
| 卷号 | 43期号:37页码:6617-6620 |
| 关键词 | Biotransformations Nitrile Hydratase Amidase Chemoenzymatic Synthesis (r)-(-)-baclofen |
| ISSN号 | 0040-4039 |
| 英文摘要 | Catalyzed by Rhodococcus sp. AJ270 microbial cells under mild conditions, a range of racemic 2-aryl-4-pentenenitriles 1 underwent effective hydrolysis to afford excellent yields of enantiomerically pure (R)-(-)-2-aryl-4-pentenamides 2 and (S)-(+)-2-aryl-4-pentenoic acids 3 in most cases. The application of this biotransformation has been shown by a two-step synthesis of (R)-(-)-baclcfen. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000177659700031 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/78995]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, MX |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, MX,Zhao, SM. Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen[J]. TETRAHEDRON LETTERS,2002,43(37):6617-6620. |
| APA | Wang, MX,&Zhao, SM.(2002).Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen.TETRAHEDRON LETTERS,43(37),6617-6620. |
| MLA | Wang, MX,et al."Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen".TETRAHEDRON LETTERS 43.37(2002):6617-6620. |
入库方式： OAI收割
来源：化学研究所
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