Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres
文献类型：期刊论文
| 作者 | Li, GM; Cai, Q; Bei, JZ; Wang, SG |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2002-09-01 |
| 卷号 | 13期号:9页码:636-643 |
| 关键词 | Polycaprolactone/poly(Ethylene Oxide) Polylacticle Tri-component Copolymer Microspheres Morphology Structure Drug Delivery Systems |
| ISSN号 | 1042-7147 |
| DOI | 10.1002/pat.287 |
| 英文摘要 | A novel tri-component copolymer, polycaprolactone/ poly(ethylene oxide)/polylactide (PCEL) was synthesized. The effect of the chemical composition on physical properties was investigated by using NMR, differential scanning calorimetry (DSC) and X-ray diffraction. Both the soft segment poly(ethylene oxide) (PEO) and polycaprolactone (PCL) could enhance the mobility of polymer chains and decrease the crystallizability of the copolymers. The polymeric microspheres, which are of interest for drug delivery systems, were prepared using an emulsification-solvent evaporation technique. By scanning electron microscopy (SEM) and atomic force microscopy (AFM), the surface morphology of the microspheres was studied. It was found that the presence of PEO segment could improve the hydrophilicity of the copolymers and the morphology of the polymeric microspheres could be altered by adjusting the chemical composition. The accumulation of PEO segments on the outer surface of the polymeric microspheres was proven by X-ray photoelectron spectroscopy (XPS). It had also been proven that the PCL segment could facilitate the movement of PEO segment to the outer surface. Copyright (C) 2002 John Wiley Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000178362500003 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/79303]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, GM,Cai, Q,Bei, JZ,et al. Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2002,13(9):636-643. |
| APA | Li, GM,Cai, Q,Bei, JZ,&Wang, SG.(2002).Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres.POLYMERS FOR ADVANCED TECHNOLOGIES,13(9),636-643. |
| MLA | Li, GM,et al."Relationship between morphology structure and composition of polycaprolactone/poly (ethylene oxide)/polylactide copolymeric microspheres".POLYMERS FOR ADVANCED TECHNOLOGIES 13.9(2002):636-643. |
入库方式： OAI收割
来源：化学研究所
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