Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension
文献类型：期刊论文
| 作者 | Yu, CL; Xu, SJ; Chen, S; Zhang, MH; Shen, T |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| 出版日期 | 2002-11-01 |
| 卷号 | 68期号:2-3页码:73-78 |
| 关键词 | Hypocrellin b Self-sensitized Photobleaching Singlet Oxygen Superoxide Endoperoxide Free Radical |
| ISSN号 | 1011-1344 |
| 英文摘要 | Hypocrellin B (HB) is a natural pigment with a promising application in the photodynamic therapy (PDT) for anticancer treatment. The photobleaching of HB in non-polar organic solvents and in liposomes in aqueous solution were investigated by the measurements of absorption spectra, quenching experiments and determination of photoproducts. Control experiments indicated that the sensitizer, oxygen and light were all essential for the photobleaching of HB, which suggested that it was mainly self-sensitized photooxidation. The illumination of HB with visible light in aerobic non-polar' solvent generated singlet oxygen efficiently [Phi(O-1(2))=0.76] which then attacked the sensitizer HB with formation of an endoperoxide product. The endoperoxide of HB was unstable at room temperature and underwent predominantly loss of singlet oxygen with regeneration of parent HB. The singlet oxygen released from the endoperoxide of HB was detected with chemical trapping experiments. When HB was embedded in EPC liposomes, no endoperoxide product and no singlet oxygen release from the photobleaching process of HB were detected. The quenching experiments indicated that the singlet oxygen mechanism (type II) played an important role in the non-polar solvent and the free radical mechanism (type 1) was predominant in liposomal aqueous solution for the photobleaching of HB. (C) 2002 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000179892100002 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/79501]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xu, SJ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, CL,Xu, SJ,Chen, S,et al. Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2002,68(2-3):73-78. |
| APA | Yu, CL,Xu, SJ,Chen, S,Zhang, MH,&Shen, T.(2002).Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,68(2-3),73-78. |
| MLA | Yu, CL,et al."Investigation of photobleaching of hypocrellin B in non-polar organic solvent and in liposome suspension".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 68.2-3(2002):73-78. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。