Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM
文献类型：期刊论文
| 作者 | Wang, ZG; Wan, LJ; Zhou, CQ; Fang, XH; Wang, C; Bai, CL |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2003-03-01 |
| 卷号 | 48期号:5页码:437-440 |
| 关键词 | Sanning Tunneling Microscopy Atomic Force Microscopy Beta-amyloid Fibrillization |
| ISSN号 | 1001-6538 |
| 英文摘要 | The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of P-amyloid(1-42)(Abeta42) on the hydrophobic graphite surface. It was found that Abeta42 were preferentially adsorbed on graphite defects such as the edges. Abeta42 peptides self-assembled into intermediate protoribrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation process of P-amyloid. |
| 语种 | 英语 |
| WOS记录号 | WOS:000181790200006 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/79645]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bai, CL |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, ZG,Wan, LJ,Zhou, CQ,et al. Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM[J]. CHINESE SCIENCE BULLETIN,2003,48(5):437-440. |
| APA | Wang, ZG,Wan, LJ,Zhou, CQ,Fang, XH,Wang, C,&Bai, CL.(2003).Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM.CHINESE SCIENCE BULLETIN,48(5),437-440. |
| MLA | Wang, ZG,et al."Study of beta-amyloid adsorption and aggregation on graphite by STM and AFM".CHINESE SCIENCE BULLETIN 48.5(2003):437-440. |
入库方式： OAI收割
来源：化学研究所
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