Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives
文献类型：期刊论文
| 作者 | Xu, SJ; Zhang, XX; Chen, S; Zhang, MH; Shen, T; Wang, ZP |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2003-09-01 |
| 卷号 | 48期号:17页码:1775-1785 |
| 关键词 | Photodynamic Therapy Epr Hypocrellins Singlet Oxygen Superoxide Anion Radical |
| ISSN号 | 1001-6538 |
| DOI | 10.1360/03wb0002 |
| 英文摘要 | Hypocrellins, as a kind of novel phototherapeutic agents, have several advantages over the clinically used hematoporphyrin derivatives, including high-excited triplet state yield, high phototoxicity, low dark toxicity, and rapid metabolism. However, they exhibit little absorption in the photodynamic window (600-900 nm) and are not water soluble, which limits their application in photodynamic therapy. Sulfonated and metal-ioned hypocrellins have been designed and synthesized to improve their water solubility. Unfortunately, the water-soluble derivatives obtained exhibit lower photodynamic activity than the parent hypocrellins. Thiolated and aminated hypocrellins have also been designed and synthesized to enlarge their photoresponse. Among them, the aminated hypocrellins possess the highest photodynamic activity. We recently have further designed and synthesized some amphiphilic aminated hypocrellin derivatives. Thus, not only the photoresponse but also the water solubility is enhanced. The experiments in vitro and in vivo on the derivatives are under way at present. |
| 语种 | 英语 |
| WOS记录号 | WOS:000185748300001 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/79687]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shen, T |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Photochem, Beijing 100080, Peoples R China 2.Harbin Engn Univ, Dept Chem Engn, Harbin 150001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, SJ,Zhang, XX,Chen, S,et al. Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives[J]. CHINESE SCIENCE BULLETIN,2003,48(17):1775-1785. |
| APA | Xu, SJ,Zhang, XX,Chen, S,Zhang, MH,Shen, T,&Wang, ZP.(2003).Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives.CHINESE SCIENCE BULLETIN,48(17),1775-1785. |
| MLA | Xu, SJ,et al."Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives".CHINESE SCIENCE BULLETIN 48.17(2003):1775-1785. |
入库方式： OAI收割
来源：化学研究所
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