Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives
文献类型：期刊论文
| 作者 | Wang, MX; Feng, GQ; Zheng, QY |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2003-06-01 |
| 卷号 | 345期号:6-7页码:695-698 |
| 关键词 | Amidase Biotransformation Acid Derivatives Enantioselectivity Hydrolysis Kinetic Resolution Nitrile Hydratase Rhodococcus Sp Aj270 2 2-dihalo-3-phenylcyclopropanecarboxylic |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.200303020 |
| 英文摘要 | Catalyzed by Rhodococcus sp. AJ270 microbial cells, trans-2,2-dihalo-3-phenylcyclopropanecarbonitriles and -amides underwent enantioselective hydrolysis under very mild conditions. Both the efficiency and enantioselectivity of the nitrile hydratase and amidase involved in the cells were strongly determined by the nature of the halogen substituent. The synthetic utility of the biocatalytic process was illustrated by an efficient and multigram scale biotransformation and synthesis of enantiopure 2,2-dichloro-3-phenylcyclopropanecarboxylic acid and amide in both enantiomeric forms. |
| 语种 | 英语 |
| WOS记录号 | WOS:000183660400011 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/79867]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, MX |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, MX,Feng, GQ,Zheng, QY. Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives[J]. ADVANCED SYNTHESIS & CATALYSIS,2003,345(6-7):695-698. |
| APA | Wang, MX,Feng, GQ,&Zheng, QY.(2003).Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives.ADVANCED SYNTHESIS & CATALYSIS,345(6-7),695-698. |
| MLA | Wang, MX,et al."Nitrile and amide biotransformations for efficient synthesis of enantiopure gem-dihalocyclopropane derivatives".ADVANCED SYNTHESIS & CATALYSIS 345.6-7(2003):695-698. |
入库方式： OAI收割
来源：化学研究所
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