Synthesis of new calix[4]arenes containing nucleoside bases
文献类型：期刊论文
| 作者 | Zeng, CC; Zheng, QY; Tang, YL; Huang, ZT |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2003-03-31 |
| 卷号 | 59期号:14页码:2539-2548 |
| 关键词 | Calixarene Nucleoside Bases Supramolecular Chemistry Synthesis |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/S0040-4020(03)00251-5 |
| 英文摘要 | A family of novel calix[4]arene derivatives containing nucleoside bases were designed and synthesized. Coupling reaction between para mono- or bis-amino calix[4]arenes 5,6 or 7 and thymin-1-ylacetic acid in the presence of DCC afforded mono- or bis-thymine-substituted calix[4]arenes 8, 9 or 10 in over 70% yield. Owing to the low solubility of adenine-N-9-ylacetic acid in DMF and DMSO and the weak nucleophilicity of aminocalix[4]arene derivatives, alternatively, the substitution reaction of bromoacetylated ammocalix[4]arenes derivatives 11, 12, 13 with adenine in the presence of sodium hydride was carried out to synthesize mono- or bis-adenine-substituted calix[4]arenes. Two kinds of isomers 15 and 16 or 17 and 18 were obtained due to the non-regiospecific alkylation of adenine, and their structures have been confirmed by C-13 NMR and H-1 NMR spectra. (C) 2003 Elsevier Science Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000181960800017 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/79969]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Huang, ZT |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, CC,Zheng, QY,Tang, YL,et al. Synthesis of new calix[4]arenes containing nucleoside bases[J]. TETRAHEDRON,2003,59(14):2539-2548. |
| APA | Zeng, CC,Zheng, QY,Tang, YL,&Huang, ZT.(2003).Synthesis of new calix[4]arenes containing nucleoside bases.TETRAHEDRON,59(14),2539-2548. |
| MLA | Zeng, CC,et al."Synthesis of new calix[4]arenes containing nucleoside bases".TETRAHEDRON 59.14(2003):2539-2548. |
入库方式： OAI收割
来源：化学研究所
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