Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings
文献类型：期刊论文
| 作者 | An, HB; Xie, J; Zhao, JQ; Li, ZS |
| 刊名 | FREE RADICAL RESEARCH
 |
| 出版日期 | 2003-09-01 |
| 卷号 | 37期号:10页码:1107-1112 |
| 关键词 | Hb-tx-100 Micelles Electron Paramagnetic Resonance Free Radicals Singlet Oxygen Photodynamic Activity |
| ISSN号 | 1071-5762 |
| DOI | 10.1080/10715760310001601056 |
| 英文摘要 | To solve the problems faced in clinical use of hypocrellins, a water-soluble preparation of Hypocrellin B (HB), HB-Triton X-100 (TX-100) micelles, was prepared. To evaluate the photodynamic activity, the free radicals ((OH)-O-. and HB .macr ) and singlet oxygen (O-1(2)) generated via photosensitization of the preparation in aqueous solution were detected by using electron paramagnetic resonance (EPR) and spectrophotometric methods. It was observed that O-1(2) was formed with a quantum yield of 0.72, similar to that for HB in organic solvents, further, hydroxyl radicals ((OH)-O-.) could also be efficiently produced by the new preparation, which have never before been detected following HB photoactivities. In addition, the semiquinone anion radicals (HB.-) could also be generated via the self-electron transfer between an excited triplet state and a ground state molecule. The accumulation of HB.- would replace that of (OH)-O-. or O-1(2) with the depletion of oxygen in the system. All these findings suggested that the HB-TX-100 micelles could play the photodynamic action through not only the type I mechanism by free radicals ((OH)-O-., O-2(.-) and HB.-) but also the type II mechanism by singlet oxygen ((1) O-2). It can be concluded further that the new preparation basically maintains the inherent photodynamic activity of HB, or even higher. |
| 语种 | 英语 |
| WOS记录号 | WOS:000185386300008 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80339]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, JQ |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Photochem, Beijing 100080, Peoples R China 2.Harbin Engn Univ, Coll Chem Engn, Harbin 150001, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, HB,Xie, J,Zhao, JQ,et al. Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings[J]. FREE RADICAL RESEARCH,2003,37(10):1107-1112. |
| APA | An, HB,Xie, J,Zhao, JQ,&Li, ZS.(2003).Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings.FREE RADICAL RESEARCH,37(10),1107-1112. |
| MLA | An, HB,et al."Photogeneration of free radicals ((OH)-O-center dot and HB center dot-) and singlet oxygen (O-1(2)) by hypocrellin b in TX-100 micelles microsurroundings".FREE RADICAL RESEARCH 37.10(2003):1107-1112. |
入库方式： OAI收割
来源：化学研究所
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