Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B
文献类型：期刊论文
| 作者 | Xu, SJ; Chen, S; Zhang, MH; Shen, T |
| 刊名 | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
 |
| 出版日期 | 2003-12-05 |
| 卷号 | 72期号:1-3页码:61-67 |
| 关键词 | Hypocrellins Photodynamic Therapy Active Oxygen Species |
| ISSN号 | 1011-1344 |
| DOI | 10.1016/j.photobiol.2003.09.001 |
| 英文摘要 | Two phenmethylamino hypocrellin B derivatives are novel photodynamic agents synthesized by a mild reaction between hypocrellin B and phemnethylamine. The red absorption of the photosensitizers is enlarged distinctly and the peri-hydroxylated perylenequinone structure of the parent HB is preserved. 9,10-diphenyl-anthracene (DPA) bleaching and electron paramagnetic resonance (EPR) spin trapping techniques were used to study the photodynamic activities of the phenmethylamino hypocrellin B derivatives in the presence of oxygen. Singlet oxygen (O-1(2)) and superoxide anion radical (O-2(-)) generated in the process of illumination of the phenmethylamino hypocrellin B in aerobic solution were observed. The photodamage of PMAHBs to MGC803 cancer cells was investigated in vitro. The results in vitro reveal that the phenmethylamino hypocrellin B derivatives show a much less significant decrease in cytotoxicity than that of their parent HB. It exhibits higher selectivity of light-orientation, which can decrease the damage to normal tissues by irradiating the tumor tissues, and so increases the drug safety. (C) 2003 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000187218900008 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80353]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhang, MH |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Photochem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, SJ,Chen, S,Zhang, MH,et al. Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2003,72(1-3):61-67. |
| APA | Xu, SJ,Chen, S,Zhang, MH,&Shen, T.(2003).Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,72(1-3),61-67. |
| MLA | Xu, SJ,et al."Synthesis, characterization and photodynamic activity of phenmethylamino-demethoxy-hypocrellin B".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 72.1-3(2003):61-67. |
入库方式： OAI收割
来源：化学研究所
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