Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin
文献类型：期刊论文
| 作者 | Guo, L; Lin, SJ; Dai, DS; Yang, YF; Qi, L; Wang, MX; Chen, Y |
| 刊名 | ANALYTICAL LETTERS
 |
| 出版日期 | 2003 |
| 卷号 | 36期号:7页码:1451-1462 |
| 关键词 | Enantioseparation Alpha-quaternary Amino Amides Capillary Electrophoresis Human Serum Albumin |
| ISSN号 | 0003-2719 |
| DOI | 10.1081/AL-120021099 |
| 英文摘要 | Enantiomers of nine cx-quaternary phenyl amino amides were synthesized and separated for the first time by capillary electrophoresis (CE). Human serum albumin (HSA) was selected as a useful anionic chiral selector by the aid of electrostatic interaction between the anionic selector and the cationic solutes. Partial-filling technique and linear polyacrylamide-coated capillaries were employed so that high concentration of HSA could be used to achieve high resolution without the loss of detection sensitivity. HSA concentration and buffer pH were shown critical and have to be optimized. It was found the hindrance effect of substituent played important role in enantioseparation. |
| 语种 | 英语 |
| WOS记录号 | WOS:000183390300013 |
| 出版者 | MARCEL DEKKER INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80431]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Y |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Biol Chem Lab, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, L,Lin, SJ,Dai, DS,et al. Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin[J]. ANALYTICAL LETTERS,2003,36(7):1451-1462. |
| APA | Guo, L.,Lin, SJ.,Dai, DS.,Yang, YF.,Qi, L.,...&Chen, Y.(2003).Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin.ANALYTICAL LETTERS,36(7),1451-1462. |
| MLA | Guo, L,et al."Enantioseparation of alpha-quaternary amino amides by capillary electrophoresis with human serum albumin".ANALYTICAL LETTERS 36.7(2003):1451-1462. |
入库方式： OAI收割
来源：化学研究所
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