Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers
文献类型：期刊论文
| 作者 | Chen, WN; Luo, WJ; Wang, SG; Bei, JZ |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2003-03-01 |
| 卷号 | 14期号:3-5页码:245-253 |
| 关键词 | Poly(L-lactide) Poly(Ethylene Glycol) Multiblock Copolymer Drug-controlled Release 5-fluorourecil |
| ISSN号 | 1042-7147 |
| DOI | 10.1002/pat.301 |
| 英文摘要 | A series of multiblock copolymers of PLLA/PEG(PLE) with high molecular weight were synthesized by coupling PLLA-PEG-PLLA triblock copolymers with succinic anhydride in the presence of N-dimethylaminopyridine (DMAP) and dicyclohexylcarbodimide (DCC). The results of the viscometry measurement, GPC and H-1 NMR, elucidated that multiblock PLE copolymers with high content of short PEG segments had been successfully obtained. The thermal properties and the crystallinity were investigated by DSC and X-ray diffraction. Men LA/EG molar ratio and the length of PEG segments were the same in both multiblock and triblock copolymers, multiblock copolymers were less crystalline than the corresponding triblock ones. Mechanical testing showed that multiblock copolymers had relatively high tensile strength and large elongation. In a word, the measurements showed that this multiblock PLE copolymers had high content of short PEG segments (Mn = 2000,4000), high molecular weight (Mw similar to 50000), high hydrophilicity, and good mechanical properties. The drug (5-Fluorourecil) release behavior of these PLE multiblock copolymers had been studied in 0.10 M pH 7.4 phosphate buffer solution (PBS), and the releasing rate could be tailored by adjusting copolymers composition. All of these results indicated that the multiblock PLE copolymers might be useful in medical applications. Copyright (C) 2003 John Wiley Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000182654500013 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80551]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Bei, JZ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, WN,Luo, WJ,Wang, SG,et al. Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2003,14(3-5):245-253. |
| APA | Chen, WN,Luo, WJ,Wang, SG,&Bei, JZ.(2003).Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers.POLYMERS FOR ADVANCED TECHNOLOGIES,14(3-5),245-253. |
| MLA | Chen, WN,et al."Synthesis and properties of poly(L-lactide)-poly (ethylene glycol) multiblock copolymers by coupling triblock copolymers".POLYMERS FOR ADVANCED TECHNOLOGIES 14.3-5(2003):245-253. |
入库方式： OAI收割
来源：化学研究所
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