Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector
文献类型：期刊论文
| 作者 | Guo, L; Lin, SJ; Yang, YF; Qi, L; Wang, MX; Chen, Y |
| 刊名 | JOURNAL OF CHROMATOGRAPHY A
 |
| 出版日期 | 2003-05-23 |
| 卷号 | 998期号:1-2页码:221-228 |
| 关键词 | Enantiomer Separation Arylglycine Amides Amides Cyclodextrins |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/S0021-9673(03)00653-8 |
| 英文摘要 | Nine racemic arylglycine amides were synthesized and successfully enantioseparated by capillary electrophoresis (CE) using highly sulfated beta-cyclodextrin (HS-beta-CD) as a chiral selector. Baseline enantioseparation of the analytes was obtained around neutral pH but not in the acidic conditions that are commonly used. HS-beta-CD content, buffer pH, type and concentration, and organic modifier concentration were studied and optimized for fast and efficient separation. A chiral CE separation system composed of 1.5% (w/v) HS-beta-CD, 0 to 10% (v/v) methanol and 20 mM 3-(N-morpholino)propanesulfonic acid at pH 6.5 was shown suitable for baseline enantioseparation of the mentioned amides within. 6 min, including simultaneous enantioseparation of three positional isomer series (methyl-, methoxyl or chloro-substituted). By using this system, D-enantionters migrated ahead of the L-enantiomers and the enantiomeric resolution order of arylglycine amides was more or less parallel to the pK(a) order of the analytes. (C) 2003 Elsevier Science B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000183589100020 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80627]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Y |
| 作者单位 | 1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Biol Chem Lab, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, L,Lin, SJ,Yang, YF,et al. Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector[J]. JOURNAL OF CHROMATOGRAPHY A,2003,998(1-2):221-228. |
| APA | Guo, L,Lin, SJ,Yang, YF,Qi, L,Wang, MX,&Chen, Y.(2003).Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector.JOURNAL OF CHROMATOGRAPHY A,998(1-2),221-228. |
| MLA | Guo, L,et al."Fast enantioseparation of arylglycine amides by capillary electrophoresis with highly sulfated-beta-cyclodextrin as a chiral selector".JOURNAL OF CHROMATOGRAPHY A 998.1-2(2003):221-228. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。