Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis
文献类型：期刊论文
| 作者 | Dong, Y; Wang, L; Shangguan, DH; Yu, X; Zhao, R; Han, HW; Liu, GQ |
| 刊名 | NEUROCHEMISTRY INTERNATIONAL
 |
| 出版日期 | 2003-07-01 |
| 卷号 | 43期号:1页码:67-72 |
| 关键词 | Hippocampus Rat Operant Glucose Lactate Microdialysis |
| ISSN号 | 0197-0186 |
| 英文摘要 | Changes of extracellular glucose and lactate in hippocampus for freely moving rats during the operant conditioned reflex were examined simultaneously. Samples of the dialysate were assayed for both glucose and lactate using in vivo microdialysis and a microbore flow injection analysis-immobilized enzyme reactor-electrochemical detection (FIA-IMER-ECD) system. Microdialysis samplings were conducted in a Skinner box where lights were delivered as conditioned stimuli (CS) paired with foot shocks as unconditioned stimuli (US). In the treatment group the concentration of glucose and lactate showed no fluctuations during the whole process. However, in the control group in which the rats were exposed to many foot shocks, lactate levels decreased by 19% below baseline during the behavioral session and glucose showed a delayed decrease (by 18%). Compared with glucose, lactate can immediately indicate the dynamic changes in brain. (C) 2003 Elsevier Science Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000181531700007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80789]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, GQ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Y,Wang, L,Shangguan, DH,et al. Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis[J]. NEUROCHEMISTRY INTERNATIONAL,2003,43(1):67-72. |
| APA | Dong, Y.,Wang, L.,Shangguan, DH.,Yu, X.,Zhao, R.,...&Liu, GQ.(2003).Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis.NEUROCHEMISTRY INTERNATIONAL,43(1),67-72. |
| MLA | Dong, Y,et al."Analysis of glucose and lactate in hippocampal dialysates of rats during the operant conditioned reflex using microdialysis".NEUROCHEMISTRY INTERNATIONAL 43.1(2003):67-72. |
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来源：化学研究所
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