Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)
文献类型：期刊论文
| 作者 | Zhao, H; Dai, DS; Li, JR; Chen, Y; Jiang, L |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2003-12-12 |
| 卷号 | 312期号:2页码:351-354 |
| 关键词 | Tar Rna Tat Peptide Quartz Crystal Microbalance Capillary Electrophoresis |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2003.10.134 |
| 英文摘要 | The interaction of poly(allylamine hydrochloride) (PAH) with TAR RNA has been studied by quartz crystal microbalance (QCM) cooperating with capillary electrophoresis (CE). Experimental results showed that PAH had high affinity for TAR RNA. In particular, PAH could disrupt the interaction of Tat peptide with TAR RNA, which is critical for HIV-1 virus replication. The approaches described here indicate that they are powerful for studying the binding processes of Tat peptide-TAR RNA and drug-TAR RNA, having great significance for the design of new drug. (C) 2003 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000186987000013 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/80859]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, Y |
| 作者单位 | Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, H,Dai, DS,Li, JR,et al. Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003,312(2):351-354. |
| APA | Zhao, H,Dai, DS,Li, JR,Chen, Y,&Jiang, L.(2003).Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride).BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,312(2),351-354. |
| MLA | Zhao, H,et al."Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 312.2(2003):351-354. |
入库方式： OAI收割
来源：化学研究所
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