Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC
文献类型：期刊论文
| 作者 | Yang, GL; Liu, HY; Li, HY; Wang, YH; Li, ZW; Chen, Y |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2003-02-01 |
| 卷号 | 57期号:3-4页码:245-247 |
| 关键词 | Column Liquid Chromatography Antidiabetic Agent N-(Trans Trans Cis-4-isopropylcyclohexylcarbonyl)-d-phenylalanine Cis-4-isopropylcyclohexanecarboxylic Acid |
| ISSN号 | 0009-5893 |
| 英文摘要 | A high-performance liquid chromatographic method is proposed for the simultaneous separation of two pairs of isomers: N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (Nateglinide) and N-(cis-4-isopropylcyclohexylcarbonyl)-D-phenylalanine, trans-4-isopropylcyclohexane-carboxylic acid and cis-4-isopropyl-cyclohexanecarboxylic acid using a C-18 column. The mobile phase is a ternary mixture of acetonitrile-methanol-0.1 M ammonium dihydrogen phosphate buffer, pH 3.0 (5:2:4, v/v/v) and UV detection at 210 nm. Precision, linearity, limit of detection and recovery were also evaluated for each compound. Satisfactory results were obtained. |
| 语种 | 英语 |
| WOS记录号 | WOS:000181318800019 |
| 出版者 | VIEWEG |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81073]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, GL |
| 作者单位 | 1.Hebei Univ, Dept Chem, Baoding 071002, Peoples R China 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, GL,Liu, HY,Li, HY,et al. Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC[J]. CHROMATOGRAPHIA,2003,57(3-4):245-247. |
| APA | Yang, GL,Liu, HY,Li, HY,Wang, YH,Li, ZW,&Chen, Y.(2003).Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC.CHROMATOGRAPHIA,57(3-4),245-247. |
| MLA | Yang, GL,et al."Separation of new antidiabetic agent, N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and three related compounds by RP-HPLC".CHROMATOGRAPHIA 57.3-4(2003):245-247. |
入库方式： OAI收割
来源：化学研究所
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