K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)
文献类型：期刊论文
| 作者 | Zhang, XY; Cao, EH; Zhang, Y; Zhou, CQ; Bai, CL |
| 刊名 | JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
 |
| 出版日期 | 2003-04-01 |
| 卷号 | 20期号:5页码:693-701 |
| 关键词 | Telomeric Dna Nanowire Structure Quadruplex Monovalent Cations Circular Dichroism Atomic Force Microscopy |
| ISSN号 | 0739-1102 |
| 英文摘要 | The telomeric DNA oligomers, d(TTAGGG)(n), where n=1, 2, 4, could self-associate into the multi-stranded structures in appropriate condition and exhibited a different CD spectra. The present of Na+ was more advantage to facilitate the formation of anti-parallel conformation, but the present of K+ enhanced their thermal stability. Spectroscopic analysis of 3, 3'-diethyloxadicarbocyanine (DODC) showed the formation of hairpin quadruplex structures for d(TTAGGG)(2) and d(TTAGGG)(4), but d(TTAGGG) could not. The four-stranded tetraplexes and branched nanowire formed in the present of K+ or Na+ alone were observed by atomic force microscopy (AFM). The ability to self-assemble of d(TTAGGG)(n), into four-stranded tetraplexes and nanowires depends strongly on the number of repeating units and ionic environment. A model to explain how these structures formed is proposed. |
| 语种 | 英语 |
| WOS记录号 | WOS:000182182000009 |
| 出版者 | ADENINE PRESS INC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81089]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Cao, EH |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XY,Cao, EH,Zhang, Y,et al. K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2003,20(5):693-701. |
| APA | Zhang, XY,Cao, EH,Zhang, Y,Zhou, CQ,&Bai, CL.(2003).K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n).JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,20(5),693-701. |
| MLA | Zhang, XY,et al."K+ and Na+-induced self-assembly of telomeric oligonucleotide d(TTAGGG)(n)".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 20.5(2003):693-701. |
入库方式： OAI收割
来源：化学研究所
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