Biodegradable poly(L-lactide)-poly(ethylene glycol) multiblock copolymer: synthesis and evaluation of cell affinity
文献类型：期刊论文
| 作者 | Wan, YQ; Chen, WN; Yang, J; Bei, JZ; Wang, SG |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2003-06-01 |
| 卷号 | 24期号:13页码:2195-2203 |
| 关键词 | Polylactide Poly(Ethylene Glycol) Multiblock Copolymer Scaffolds Tissue Engineering |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/S0142-9612(03)00107-8 |
| 英文摘要 | A series of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers (Multi-PLE) with high molecular weight were synthesized and successfully used to fabricate three-dimensional scaffolds. Using mouse NIH 3T3 fibroblasts as model cells, the cell affinity of various Multi-PLE copolymers was evaluated and compared with that of poly(L-lactide) (PLLA) by means of cell attachment efficiency measurement, scanning electron microscopy observation and MTT assay. On one hand, the results showed that the cell attachment efficiency on Multi-PLE 4/1(4/1 refers to the molar ratio of lactidyl units to ethylene oxide units) films was close to that on PLLA film, however, the other Multi-PLE films exhibited much lower cell attachment efficiency than PLLA film, such as Multi-PLE 2/1 and Multi-PLE 1/1, which had higher PEG content. On the other hand, it was interesting to find that cell proliferation on Multi-PLE4/1 and Multi-PLE2/1 scaffolds was better than that on PLLA scaffold, which was closely related to the improved hydrophilicity of Multi-PLE copolymers due to the incorporation of PEG in comparison with pure PLLA. The Multi-PLE copolymer scaffolds with appropriate hydrophilicity were in favor of mass transportation, and then of cell proliferation and cell affinity. It meant that the cell proliferation would be much improved by increasing the hydrophilicity of the three-dimensional scaffolds, which even outweighed the disadvantages of the cell attachment efficiency reduction with the incorporation of PEG. (C) 2003 Elsevier Science Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000182280400008 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81147]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, YQ,Chen, WN,Yang, J,et al. Biodegradable poly(L-lactide)-poly(ethylene glycol) multiblock copolymer: synthesis and evaluation of cell affinity[J]. BIOMATERIALS,2003,24(13):2195-2203. |
| APA | Wan, YQ,Chen, WN,Yang, J,Bei, JZ,&Wang, SG.(2003).Biodegradable poly(L-lactide)-poly(ethylene glycol) multiblock copolymer: synthesis and evaluation of cell affinity.BIOMATERIALS,24(13),2195-2203. |
| MLA | Wan, YQ,et al."Biodegradable poly(L-lactide)-poly(ethylene glycol) multiblock copolymer: synthesis and evaluation of cell affinity".BIOMATERIALS 24.13(2003):2195-2203. |
入库方式： OAI收割
来源：化学研究所
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