Morphology and levonorgestrel release behavior of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymeric microspheres
文献类型：期刊论文
| 作者 | Li, GM; Cai, Q; Bei, JZ; Wang, SG |
| 刊名 | POLYMERS FOR ADVANCED TECHNOLOGIES
 |
| 出版日期 | 2003-03-01 |
| 卷号 | 14期号:3-5页码:239-244 |
| 关键词 | Polycaprolactone/poly(Ethylene Oxide)/polylactide Tri-component Copoymer Microspheres Morphology Controlled Release Levonorgestrel |
| ISSN号 | 1042-7147 |
| DOI | 10.1002/pat.300 |
| 英文摘要 | A novel polycaprolactone/poly(ethylene oxide)/polylactide (PCEL) tri-component copolymer was synthesized and used for the investigation of lipid-soluble drug levonorgestrel (LNG), in vitro release from drug-loaded microspheres. The hydrophilicity of the PCEL strongly depended on the content of the poly(ethylene oxide) (PEO) segment. LNG-loaded biodegradable polylactide (PLA) and PCEL microspheres have been successfully prepared by using an oil-in-water emulsion and solvent-evaporation method. The effect of various factors such as chemical composition and molecular weight on the morphology of the microspheres produced has been investigated. The influence of chemical composition and hydrophilicity on the drug-loading efficiency has also been investigated. The release behaviors of LNG in vitro from the PLA and PCEL microspheres were determined. The drug-loading efficiency and LNG-release behavior closely depended on the chemical composition and morphology of the polymeric microspheres. With the addition of a PEO segment in the copolymer chains, the structure of the microspheres became porous which would lower the drug-loading efficiency and speed up the drug-release rate. Copyright (C) 2003 John Wiley Sons, Ltd. |
| 语种 | 英语 |
| WOS记录号 | WOS:000182654500012 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81241]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, SG |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, GM,Cai, Q,Bei, JZ,et al. Morphology and levonorgestrel release behavior of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymeric microspheres[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2003,14(3-5):239-244. |
| APA | Li, GM,Cai, Q,Bei, JZ,&Wang, SG.(2003).Morphology and levonorgestrel release behavior of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymeric microspheres.POLYMERS FOR ADVANCED TECHNOLOGIES,14(3-5),239-244. |
| MLA | Li, GM,et al."Morphology and levonorgestrel release behavior of polycaprolactone/poly(ethylene oxide)/polylactide tri-component copolymeric microspheres".POLYMERS FOR ADVANCED TECHNOLOGIES 14.3-5(2003):239-244. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。