Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters
文献类型：期刊论文
| 作者 | Yang, YN; Lou, L; Liang, QZ; Chen, XS; Jing, XB |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2004 |
| 卷号 | 25期号:1页码:162-165 |
| 关键词 | Rifampin Plga Microspheres Biodegradable Polymer Controlled Drug-release Lung Targcting |
| ISSN号 | 0251-0790 |
| 英文摘要 | Microspheres containing antiphthisic drug Rifampin were prepared from poly (lactide-co-glycolide) (PLGA) as carrier by emulsion and solvent evaporation method. The conditions of the microsphere preparation such as the drug/carrier molar ratio, the volume ratio of organic solvent to water, PLGA concentration in organic solvent, speed of emulsification, kind of stabilizer, relative molecular weight of PLGA, LLA/GA mass ratio were discussed. The surface morphology of the microspheres in original and degraded states was observed by SEM. The mean diameter and drug content of microspheres were examined, and the drug release in vitro was evaluated. The morphology of the microspheres prepared from PLGA and by 1% gelatin as the stabilizer was integral with 10-30 mum diameter range, 24.3% average drug content, 42-84 d drug-release time. The drug-release kinetics with zero order satisfies the requirements of controlled drug-release. |
| 语种 | 英语 |
| WOS记录号 | WOS:000188470400041 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81561]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, XS |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Changchun Univ Technol, Dept Chem Engn, Changchun, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, YN,Lou, L,Liang, QZ,et al. Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2004,25(1):162-165. |
| APA | Yang, YN,Lou, L,Liang, QZ,Chen, XS,&Jing, XB.(2004).Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,25(1),162-165. |
| MLA | Yang, YN,et al."Preparation and in vitro release of rifampin microspheres encapsulated in biodegradable polyesters".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 25.1(2004):162-165. |
入库方式： OAI收割
来源：化学研究所
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