Molecular recognition in in-situ nateglinide imprinted chiral stationary phase
文献类型：期刊论文
| 作者 | Yin, JF; Yang, GL; Zhang, YH; Liu, HY; Chen, Y |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2004-10-14 |
| 卷号 | 62期号:19页码:1922-1926 |
| 关键词 | Molecularly Imprinted Polymer Chiral Stationary Phase In-situ Polymerization Chiral Separation Nateglinide |
| ISSN号 | 0567-7351 |
| 英文摘要 | Nateglinide has been employed as template for the in-situ preparation of molecularly imprinted continuous rod applied as liquid chromatographic chiral stationary phases for the separation of the enantiomers of the nateglinide. It was shown that the nateglinide-imprinted polymer (nateglinide-MIP) was capable of recognizing the enantiomeric difference of the template and its L-enantiomer, while the non-imprinted polymer had no such ability. The thermodynamic parameters in the chiral separation process were cauculated, and Scatchard analysis was performed to investigate the thermodynamic characteristics and binding characteristics of the nateglinide-MIP stationary phase. The excellent enantioselectivities for the imprinted substance, together with the continuous and homogenous structures of the in-situ MIP, boded well their use as chiral stationary phase. |
| 语种 | 英语 |
| WOS记录号 | WOS:000224536500013 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81765]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yin, JF |
| 作者单位 | 1.Chinese Acad Sci, Ctr Mol Sci, Beijing 100080, Peoples R China 2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, JF,Yang, GL,Zhang, YH,et al. Molecular recognition in in-situ nateglinide imprinted chiral stationary phase[J]. ACTA CHIMICA SINICA,2004,62(19):1922-1926. |
| APA | Yin, JF,Yang, GL,Zhang, YH,Liu, HY,&Chen, Y.(2004).Molecular recognition in in-situ nateglinide imprinted chiral stationary phase.ACTA CHIMICA SINICA,62(19),1922-1926. |
| MLA | Yin, JF,et al."Molecular recognition in in-situ nateglinide imprinted chiral stationary phase".ACTA CHIMICA SINICA 62.19(2004):1922-1926. |
入库方式： OAI收割
来源：化学研究所
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