Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase
文献类型：期刊论文
| 作者 | Zhang, ZF; Yang, GL; Liang, GJ; Liu, HY; Chen, Y |
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2004-02-18 |
| 卷号 | 34期号:3页码:689-693 |
| 关键词 | Chiral Separation Tamsulosin (5-[(2r)-2-{[2-(2-ethoxyphenoxy) Ethyl] Amino}-propyl]-2-methoxy-benzenesulfonamide) Isomer Cellulose Tris (3 5-dimethylphenylcarbamate) Stationary Phase |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/S0731-7085(03)00555-7 |
| 英文摘要 | A high-performance liquid chromatographic (HPLC) method was developed for the chiral separation of an antagonist of alpha 1A adrenoceptors, tamsulosin and its S-isomer. Baseline separation of the isomers was achieved within 35 min on a CHIRALCEL OD-RH column with a binary solvent mixture of 50 mmol l(-1) KPF6-acetonitrile (v/v (70:30), pH 5.0) as the optimized mobile phase. The detection limits and quantification limits of both R-isomer and S-isomer were 0.11 and 0.44 ng, respectively. The R.S.D. values of peak-area for the two isomer were 0.42% (of peak-height: 0.77%) for R-isomer and 0.64% (of peak-height:0.92%) for S-isomer (n = 5). (C) 2003 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000189212100026 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81845]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, GL |
| 作者单位 | 1.Hebei Univ, Coll Chem & Environm Sci, Dept Chem, Baoding 071002, Hebei, Peoples R China 2.Air Force PLA, Gen Hosp, Beijing 100850, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, ZF,Yang, GL,Liang, GJ,et al. Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2004,34(3):689-693. |
| APA | Zhang, ZF,Yang, GL,Liang, GJ,Liu, HY,&Chen, Y.(2004).Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,34(3),689-693. |
| MLA | Zhang, ZF,et al."Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 34.3(2004):689-693. |
入库方式： OAI收割
来源：化学研究所
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