Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique
文献类型：期刊论文
| 作者 | Yan, HY; Yang, GL; Qiao, FX; Yi, C |
| 刊名 | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| 出版日期 | 2004-09-21 |
| 卷号 | 36期号:1页码:169-174 |
| 关键词 | Mekc On-line Sweeping Nateglinide Plasma |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2004.05.001 |
| 英文摘要 | A micellar electrokinetic chromatography (MEKC) method was developed for the determination of nateglinide in animal plasma by on-line sweeping technique, in which plasma samples were simply deproteinized with acetonitrile, and analyzed with 16 mmol/L NaH2PO4 + 6 mmol/L Na2B4O7 + 60 mmol/L sodium dodecyl sulfate (SDS) (pH 7.14) as the running buffer, a fused-silica capillary as the separation tube, 21 kV as the running voltage and UV detection at 214 nm. Under these conditions, more than 100-fold enrichment of nateglinide was obtained with the good linear relation in the range of nateglinide plasma concentration 0.2-7 mg/L (R = 0.998). The method could be applied successfully to determine trace drugs in clinical analysis. (C) 2004 Published by Elsevier B.V. |
| 语种 | 英语 |
| WOS记录号 | WOS:000224328000022 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81859]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, GL |
| 作者单位 | 1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Beijing 100080, Peoples R China 2.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, HY,Yang, GL,Qiao, FX,et al. Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2004,36(1):169-174. |
| APA | Yan, HY,Yang, GL,Qiao, FX,&Yi, C.(2004).Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,36(1),169-174. |
| MLA | Yan, HY,et al."Determination of nateglinide in animal plasma by micellar electrokinetic chromatography and on-line sweeping technique".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 36.1(2004):169-174. |
入库方式： OAI收割
来源：化学研究所
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