Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone)
文献类型：期刊论文
| 作者 | Deng, MX; Wang, R; Rong, GZ; Sun, JR; Zhang, XF; Chen, XS; Jing, XB |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2004-08-01 |
| 卷号 | 25期号:17页码:3553-3558 |
| 关键词 | Biodegradation Poly(Epsilon-caprolactone) Poly(Ethylene Oxide) Poly(Gamma-benzyl-l-glutamic Acid) Triblock Copolymer |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2003.10.018 |
| 英文摘要 | A novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PBLG-PEO-PCL) was synthesized by a new approach in the following three steps: (1) sequential anionic ring opening polymerization (ROP) of ethylene oxide and epsilon-caprolactone with an acetonitrile/potassium naphthalene initiator system to obtain a diblock copolymer CN-PEO-PCL with a cyano end-group; (2) conversion of the CN end-group into NH2 end-group by hydrogenation to obtain NH2-PEO-PCL; (3) ROP of gamma-benzyl-L-glutamate-N-carboxyanhydrides (Bz-L-GluNCA) with NH2-PEO-PCL as macroinitiator to obtain the target triblock copolymer. The structures from CN-PEO precursor to the triblock copolymers were confirmed by FT-IR and H-1 NMR spectroscopy, and their molecular weights were measured by gel permeation chromatography. The monomer of Bz-L-GluNCA can react almost quantitatively with the amino end-groups of NH2-PEO-PCL macroinitiator by ROP. (C) 2003 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000220558200023 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/81879]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Chen, XS |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, MX,Wang, R,Rong, GZ,et al. Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone)[J]. BIOMATERIALS,2004,25(17):3553-3558. |
| APA | Deng, MX.,Wang, R.,Rong, GZ.,Sun, JR.,Zhang, XF.,...&Jing, XB.(2004).Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone).BIOMATERIALS,25(17),3553-3558. |
| MLA | Deng, MX,et al."Synthesis of a novel structural triblock copolymer of poly(gamma-benzyl-L-glutamic acid)-b-poly(ethylene oxide)-b-poly(epsilon-caprolactone)".BIOMATERIALS 25.17(2004):3553-3558. |
入库方式： OAI收割
来源：化学研究所
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