alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study
文献类型：期刊论文
| 作者 | Tanaka, Y; Han, HW; Hagishita, T; Fukui, F; Liu, GQ; Ando, S |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2004-02-26 |
| 卷号 | 357期号:1页码:9-12 |
| 关键词 | Alpha-sialylcholesterol Acetylcholine Glutamate Microdialysis Hippocampus Fmi-43 Synaptosomes Rats |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2003.11.062 |
| 英文摘要 | The effects of a-sialylcholesterol (alpha-SC), a synthetic ganglioside analogue, on synaptic neurotransmission were studied using in vivo microdialysis technique. Application of ot-SC through a microdialysis probe enhanced high potassium-evoked release of acetylcholine and glutamate in the hippocampal CA3 region of Wistar rats. The experiments using synaptosomes and FM1-43, a fluorescent styryl dye used for studies of neurotransmitter release mechanisms, showed that ot-SC increased depolarization-induced loss of dye but it did not evoke the dye loss at resting condition. These results indicate that alpha-SC promotes a depolarization-induced exocytotic neurotransmitter release in the brain under in vivo conditions. Application of alpha-SC increased the level of glutamate but not that of acetylcholine, suggesting that a-SC affects spontaneous glutamate release and/or transport system at the brain region. (C) 2003 Elsevier Ireland Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000189169800003 |
| 出版者 | ELSEVIER SCI IRELAND LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82201]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Tanaka, Y |
| 作者单位 | 1.Tokyo Metropolitan Inst Gerontol, Div Neurosci & Brain Funct, Neuronal Funct Res Grp, Itabashi Ku, Tokyo 1730015, Japan 2.Chinese Acad Sci, Inst Chem, Div Analyt Chem Life Sci, Beijing 100080, Peoples R China 3.Japan Sci & Technol Cooperat, Domest Res Fellowship, Kawaguchi, Saitama 3320012, Japan |
| 推荐引用方式 GB/T 7714 | Tanaka, Y,Han, HW,Hagishita, T,et al. alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study[J]. NEUROSCIENCE LETTERS,2004,357(1):9-12. |
| APA | Tanaka, Y,Han, HW,Hagishita, T,Fukui, F,Liu, GQ,&Ando, S.(2004).alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study.NEUROSCIENCE LETTERS,357(1),9-12. |
| MLA | Tanaka, Y,et al."alpha-sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study".NEUROSCIENCE LETTERS 357.1(2004):9-12. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。