Novel electrochemical method for sensitive determination of homocysteine with carbon nanotube-based electrodes
文献类型：期刊论文
| 作者 | Gong, KP; Dong, Y; Xiong, SX; Chen, Y; Mao, LQ |
| 刊名 | BIOSENSORS & BIOELECTRONICS
 |
| 出版日期 | 2004-09-15 |
| 卷号 | 20期号:2页码:253-259 |
| 关键词 | Electrocatalysis Biosensor Carbon Nanombe Homocysteine Auto-oxidation |
| ISSN号 | 0956-5663 |
| DOI | 10.1016/j.bios.2004.01.014 |
| 英文摘要 | An electrochemical method has been successfully demonstrated for sensitive determination of homocysteine (HcySH) with carbon nanotube (CNT)-modified glassy carbon (GC) electrodes. Cyclic voltammetric results clearly show that carbon nanotubes, especially those pretreated with nitric acid, possess an excellent electrocatalytic activity toward the oxidation of HcySH at a low potential (0.0 V versus Ag/AgCl). The remarkable catalytic property of the acid-pretreated CNTs, which is essentially associated with oxygen-containing moieties introduced on the tube surface, has been further exploited as a sensitive determination scheme for HcySH. Continuous-flow amperometric results suggest that the CNT-based electrodes (p-CNT/Nafion/GC), which were prepared by using Nation to solubilize and further immobilize CNTs on GC electrodes, show striking analytical properties of good stability and reproducibility and strong ability against electrode fouling. Such analytical properties, along with the low operation potential, substantially enable a reliable and sensitive determination of HcySH with a good dynamic linearity up to 60 muM and a detection limit of 0.06 muM (S/N = 3). The catalytic mechanism and the possible application of the as-prepared p-CNT/Nafion/GC electrodes for the study of the auto-oxidation of HcySH are also demonstrated and discussed. (C) 2004 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000224034400016 |
| 出版者 | ELSEVIER ADVANCED TECHNOLOGY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82449]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Mao, LQ |
| 作者单位 | Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, KP,Dong, Y,Xiong, SX,et al. Novel electrochemical method for sensitive determination of homocysteine with carbon nanotube-based electrodes[J]. BIOSENSORS & BIOELECTRONICS,2004,20(2):253-259. |
| APA | Gong, KP,Dong, Y,Xiong, SX,Chen, Y,&Mao, LQ.(2004).Novel electrochemical method for sensitive determination of homocysteine with carbon nanotube-based electrodes.BIOSENSORS & BIOELECTRONICS,20(2),253-259. |
| MLA | Gong, KP,et al."Novel electrochemical method for sensitive determination of homocysteine with carbon nanotube-based electrodes".BIOSENSORS & BIOELECTRONICS 20.2(2004):253-259. |
入库方式： OAI收割
来源：化学研究所
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