Core-cross-linked polymeric micelles as paclitaxel carriers
文献类型：期刊论文
| 作者 | Shuai, XT; Merdan, T; Schaper, AK; Xi, F; Kissel, T |
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2004-05-01 |
| 卷号 | 15期号:3页码:441-448 |
| ISSN号 | 1043-1802 |
| DOI | 10.1021/bc034113u |
| 英文摘要 | Cross-linkable di- and triblock copolymers of poly(c-caprolactone) (PCL) and monomethoxyl poly(ethylene glycol) (MPEG) were synthesized. These amphiphilic copolymers self-assembled into nanoscale micelles capable of encapsulating hydrophobic paclitaxel in their hydrophobic cores in aqueous solutions. To further enhance their thermodynamic stability, the micelles were cross-linked by radical polymerization of the double bonds introduced into the PCL blocks. Reaction conditions were found to significantly affect both the cross-linking efficiency and the micelle size. The encapsulation of paclitaxel into the micelles was confirmed by the proton nuclear magnetic resonance (H-1 NMR) spectroscopy. Encouragingly, paclitaxel-loading efficiency of micelles was enhanced significantly upon micelle core-cross-linking. Both the micelle size and the drug loading efficiency increased markedly with increasing the PCL block lengths, no matter if the micelles were core-crosslinked or not. However, paclitaxel-loading did not obviously affect the micelle size or size distribution. The cross-linked micelles exhibited a significantly enhanced thermodynamic stability against dilution with aqueous solvents. The efficient cellular uptake of paclitaxel loaded in the nanomicelles was demonstrated by confocal laser scanning microscopy (CLSM) imaging. This new biodegradable nanoscale carrier system merits further investigations for parenteral drug delivery. |
| 语种 | 英语 |
| WOS记录号 | WOS:000221563300002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82485]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Kissel, T |
| 作者单位 | 1.Univ Marburg, Dept Pharmaceut & Biopharm, D-35032 Marburg, Germany 2.Univ Marburg, Dept Geosci, D-35032 Marburg, Germany 3.Univ Marburg, Ctr Mat Sci, D-35032 Marburg, Germany 4.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shuai, XT,Merdan, T,Schaper, AK,et al. Core-cross-linked polymeric micelles as paclitaxel carriers[J]. BIOCONJUGATE CHEMISTRY,2004,15(3):441-448. |
| APA | Shuai, XT,Merdan, T,Schaper, AK,Xi, F,&Kissel, T.(2004).Core-cross-linked polymeric micelles as paclitaxel carriers.BIOCONJUGATE CHEMISTRY,15(3),441-448. |
| MLA | Shuai, XT,et al."Core-cross-linked polymeric micelles as paclitaxel carriers".BIOCONJUGATE CHEMISTRY 15.3(2004):441-448. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。