Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique
文献类型：期刊论文
| 作者 | Zhao, YY; Yang, GL; Yan, HY; Yu, Q; Chen, Y |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2004-04-01 |
| 卷号 | 32期号:4页码:485-488 |
| 关键词 | Micelle Capillary Electrophoresis On-line Sweeping Concentration Technique Drug Concentration In Blood Ciprofloxacin |
| ISSN号 | 0253-3820 |
| 英文摘要 | A method for the electrmination of trace ciprofloxacin in plasma was established by the micelle capillary electrophoresis on-line sweeping enrichment technique. The effect of pH in background solution, the concentration of sodium dodecyl sulfate (SDS), injection time, plasma sample pretreatment method on the enrichment of ciprofloxacin was investigated. The experiments were carried out in an uncoated fused silica capillary (55 cm x 75 mum i.d., effective length 47 cm) under the following conditions: background solution of 30 mmol/L borate and 80 mmol/L SDS (pH 9.40); detection wavelength 254 nm; run voltage 18 kV. The plasma sample was directly injected into the column after it was simply deproteinized with acetonitrile. Up to 600-fold concentration of the ciprofloxacin can be enriched. The good linear relation was obtained (r = 0.999, n = 8) in range of 0.04 similar to 10 mg/L. The detection limit was 0.01 mg/L, this method has been applied successfully to determine trace drugs in clinical analysis. |
| 语种 | 英语 |
| WOS记录号 | WOS:000221218100016 |
| 出版者 | SCIENCE CHINA PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/82523]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, YY |
| 作者单位 | 1.Hebei Med Coll Continuing Educ, Expt Ctr, Baoding 071000, Peoples R China 2.Hebei Univ, Coll Chem & Environm Sci, Baoding 071000, Peoples R China 3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, YY,Yang, GL,Yan, HY,et al. Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2004,32(4):485-488. |
| APA | Zhao, YY,Yang, GL,Yan, HY,Yu, Q,&Chen, Y.(2004).Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,32(4),485-488. |
| MLA | Zhao, YY,et al."Determination of ciprofloxacin in plasma by micelle capillary electrophoresis on-line sweeping concentration technique".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 32.4(2004):485-488. |
入库方式： OAI收割
来源：化学研究所
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