Optical toxicity of triphenyl phosphate in zebrafish larvae
文献类型：期刊论文
| 作者 | Shi, Qipeng1,2; Wang, Zongyi3,4; Chen, Lianguo1; Fu, Juanjuan1,2; Han, Jian1; Hu, Bing3,4; Zhou, Bingsheng1 |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2019-05-01 |
| 卷号 | 210页码:139-147 |
| 关键词 | Triphenyl phosphate Opsin Retina Optical toxicity Zebrafish |
| ISSN号 | 0166-445X |
| DOI | 10.1016/j.aquatox.2019.02.024 |
| 通讯作者 | Han, Jian(hanjian@ihb.ac.cn) |
| 英文摘要 | Triphenyl phosphate (TPhP) has been shown to cause developmental neurotoxicty. Considering the visual system is a sensitive target, in the present study, we investigated the potential toxicity of TPhP on the visual development and function in zebrafish larvae. Embryos were exposed to 0, 0.1, 1, 10, and 30 mu g/L TPhP from 2 to 144 h post-fertilization (hpf). The transcription of photoreceptor opsin genes, and histopathological changes in the retina and visual behavior (optokinetic and phototactic responses) were evaluated. TPhP significantly downregulated the transcription of opsin genes (zfrho, opn1sw1, opn1sw2, opn1mw1, opn1mw2, opn1mw3, opn1mw4, opn1lw1 and opn1lw2) in all exposure groups. Histopathological analysis revealed that the areas of the outer nuclear layer (ONL), inner nuclear layer (INL), and inner plexiform layer (IPL) of the retina were significantly reduced in the 10 and 30 mu g/L TPhP groups. The number of ganglion cells was reduced significantly in the 30 mu g/L group. The optokinetic response (OKR) and phototactic response showed dose-dependent decreases caused by impaired visual function, which was confirmed by unchanged locomotor activity. The results indicated that exposure to environmentally relevant concentrations of TPhP could inhibit the transcription of genes related to visual function and impair retinal development, thus leading to visual impairment in zebrafish larvae. |
| WOS关键词 | ORGANOPHOSPHORUS FLAME RETARDANTS ; EARLY-LIFE STAGES ; ACUTE EXPOSURE ; VISUAL-SYSTEM ; DEVELOPMENTAL NEUROTOXICITY ; THYROID DISRUPTION ; GENE-EXPRESSION ; ADULT ; PLASTICIZERS ; RESPONSES |
| 资助项目 | National Natural Science Foundation of China[21737005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB14040103] ; State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ11] |
| WOS研究方向 | Marine & Freshwater Biology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000464481800013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology ; State Key Laboratory of Freshwater Ecology and Biotechnology |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/27654]  |
| 专题 | 水生生物研究所_水环境工程研究中心 |
| 通讯作者 | Han, Jian |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Microscale Sch Life Sci, Hefei Natl Lab Phys Sci, Hefei, Anhui, Peoples R China 4.Univ Sci & Technol China, Chinese Acad Sci, Sch Life Sci, Key Lab Brain Funct & Dis, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Qipeng,Wang, Zongyi,Chen, Lianguo,et al. Optical toxicity of triphenyl phosphate in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2019,210:139-147. |
| APA | Shi, Qipeng.,Wang, Zongyi.,Chen, Lianguo.,Fu, Juanjuan.,Han, Jian.,...&Zhou, Bingsheng.(2019).Optical toxicity of triphenyl phosphate in zebrafish larvae.AQUATIC TOXICOLOGY,210,139-147. |
| MLA | Shi, Qipeng,et al."Optical toxicity of triphenyl phosphate in zebrafish larvae".AQUATIC TOXICOLOGY 210(2019):139-147. |
入库方式： OAI收割
来源：水生生物研究所
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