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Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)

文献类型：期刊论文

作者Wang, Kai-Zhuo1; Feng, Lin1,2,3; Jiang, Wei-Dan1,2,3; Wu, Pei1,2,3; Liu, Yang1,2,3; Jiang, Jun1; Kuang, Sheng-Yao4; Tang, Ling4; Zhang, Yong-An5; Zhou, Xiao-Qiu1,2,3
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2019-03-01
卷号86页码:814-831
ISSN号1050-4648
关键词Gossypol Grass carp (Ctenopharyngodon idella) Intestinal immunity NF-kappa B signalling TOR signalling
DOI10.1016/j.fsi.2018.12.014
通讯作者Zhou, Xiao-Qiu(xqzhouqq@tom.com)
英文摘要The present study explored the effects of dietary gossypol on the gut health of on-growing grass carp. The fish were fed six diets containing different levels of free gossypol (0, 121.38, 243.94, 363.89, 759.93 and 1162.06 mg/kg diet) from gossypol-acetic acid for 60 days and then challenged with Aeromonas hydrophila for 14 days. The results showed that dietary gossypol (1) could aggravate enteritis and damage the structure of intestinal epithelial cells, (2) decreased the lysozyme (LZ) and Acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents, and it down-regulated the Hepcidin (rather than distal intestine (DI)), immunoglobulin Z (IgZ), liver-expressed antimicrobial peptide (LEAP)-2B, Mucin2 and beta-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and DI, (3) up-regulated intestinal pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interferon gamma 2 (IFN-gamma 2), interleukin 1 beta (IL-1 beta), IL-6 (only in PI), IL-8 and IL-12p35 mRNA levels partly related to nuclear factor kappa B (NF-kappa B) signalling, and (4) down-regulated the mRNA levels of anti-inflammatory cytokines such as transforming growth factor (TGF)-beta 1, TGF-beta 2, interleukin 4/13A (IL-4/13A) (except IL-4/13B), IL-10 and IL-11 partly relating to target of rapamycin (TOR) signalling in the intestines of on-growing grass carp. Moreover, the dietary gossypol had no impact on the LEAP-2A, IL-12P40, IL-17D, IL-10, NF-kappa Bp52, IKK alpha and eIF4E-binding proteins 2 (4E-BP2) mRNA levels in the intestines. Finally, based on the intestinal histopathological results, enteritis morbidity, LZ activity and IgM content, the safe dose of gossypol in the diets for on-growing grass carp should be less than 103.42 mg/kg diet.
WOS关键词NF-KAPPA-B ; TIGHT JUNCTION PROTEIN ; GROWTH-PERFORMANCE ; STRUCTURAL INTEGRITY ; HEAD KIDNEY ; AEROMONAS-HYDROPHILA ; SIGNALING PATHWAYS ; ADAPTIVE IMMUNITY ; ATLANTIC SALMON ; OXIDATIVE STRESS
资助项目National Basic Research Program of China (973 Program)[2014CB138600] ; National Department Public Benefit Research Foundation (Agriculture) of China[201003020] ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China[2014NZ0003] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2012NC0007] ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2013NC0045] ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China[2015CC0011] ; Earmarked Fund for China Agriculture Research System[CARS-45] ; Natural Science Foundation for Young Scientists of Sichuan Province[2014JQ0007] ; Foundation of Sichuan Youth Science and Technology Innovation Research Team[2017TD0002]
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号WOS:000459528400089
资助机构National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Basic Research Program of China (973 Program) ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; National Department Public Benefit Research Foundation (Agriculture) of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture), Science and Technology Support Program of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Earmarked Fund for China Agriculture Research System ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Natural Science Foundation for Young Scientists of Sichuan Province ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team ; Foundation of Sichuan Youth Science and Technology Innovation Research Team
源URL[http://ir.ihb.ac.cn/handle/342005/28038]  
专题水生生物研究所_水生生物分子与细胞生物学研究中心
通讯作者Zhou, Xiao-Qiu
作者单位1.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China
2.Sichuan Agr Univ, Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China
3.Sichuan Agr Univ, China Minist Educ, Key Lab Anim Dis Resistance Nutr, Chengdu 611130, Sichuan, Peoples R China
4.Sichuan Acad Anim Sci, Inst Anim Nutr, Chengdu 610066, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Kai-Zhuo,Feng, Lin,Jiang, Wei-Dan,et al. Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)[J]. FISH & SHELLFISH IMMUNOLOGY,2019,86:814-831.
APA Wang, Kai-Zhuo.,Feng, Lin.,Jiang, Wei-Dan.,Wu, Pei.,Liu, Yang.,...&Zhou, Xiao-Qiu.(2019).Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella).FISH & SHELLFISH IMMUNOLOGY,86,814-831.
MLA Wang, Kai-Zhuo,et al."Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)".FISH & SHELLFISH IMMUNOLOGY 86(2019):814-831.

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来源：水生生物研究所

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