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Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection

文献类型：期刊论文

作者Zhang, Peiyu1,2; Fu, Lele1,2; Liu, Haokun1; Huda, Noor-Ul1,2; Zhu, Xiaoming1; Han, Dong1,3; Jin, Junyan1; Yang, Yunxia1; Kim, Yang-Su4; Xie, Shouqi1
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2019-03-01
卷号86页码:913-921
关键词5'-IMP Carassius auratus gibelio Immunity Disease resistance Aeromonas hydrophila
ISSN号1050-4648
DOI10.1016/j.fsi.2018.12.016
通讯作者Liu, Haokun(liuhaokun@ihb.ac.cn)
英文摘要The present study was conducted to evaluate dietary inosine 5'-monophosphate (5'-IMP) on growth, immune genes expression and disease resistance against Aeromonas hydrophila in juvenile gibel carp (Carassius auratus gibelio var. CAS III) (initial body weight: 7.48 g). Six diets were formulated containing exogenous 5'-IMP at three gradient levels (0, 0.1% and 0.2%) in the high dietary fishmeal group (15% fishmeal: Dl, D2, D3) and in the high dietary soybean meal group (33% soybean meal: D4, D5, D6). Each diet was randomly allotted to triplicate tanks in a recirculating system. After the feeding trial, fish were exposed to Aeromonas hydrophila challenge. Hematological and immunological responses were analyzed before and after challenge. The results indicated that feeding rate in all 5'-IMP supplemented treatments (D2, D3, D5 and D6) and daily growth coefficient in D5 and D6 were reduced compared with those of respective control treatments (Dl and D4) without 5'-IMP addition (P < 0.05). The cumulative survival rates were numerically improved by dietary 5'-IMP supplementation (P > 0.05). Compared with the respective control treatment, in the high fishmeal group, plasma SOD and MPO were significantly elevated in D3 at the end of feeding trial (P < 0.05), plasma SOD and lysozyme were significantly increased in D3 after bacterial challenge (P < 0.05); in high soybean meal group, plasma lysozyme activity was significantly elevated in D5 post bacterial challenge (P < 0.05). Most of the expression of immune related genes (intelectin, major histocompatibility complex class II beta (MHC II beta), Complement 3 (C3), Complement component C7-1 (ccC7), lysozyme C, Interleukin 1 beta (IL-1 beta), Tumor necrosis factor alpha 1 (TNF-alpha 1), Transforming growth factor-beta (TGE-beta) and Interleukin 8 (IL-8)) in spleen, kidney and liver of the fish were significantly affected by supplementation of 5'-IMP at the end of feeding trial and post bacterial challenge. Additionally, adding 5'-IMP in high soybean meal diets exerted further effects of promoting immunity than counterparts in high fishmeal diets. Considering enhanced disease resistance, the immunopotentiation of 5'-IMP was manifested when the addition level was 0.1% in high soybean meal diets and 0.2% in high fishmeal diets.
WOS关键词ENDOTHELIAL-CELLS ; GUT MORPHOLOGY ; RAINBOW-TROUT ; NITRIC-OXIDE ; JUVENILE AMBERJACK ; DISEASE RESISTANCE ; STRESS RESISTANCE ; INNATE IMMUNITY ; NILE TILAPIA ; NUCLEOTIDES
资助项目National Natural Science Foundation of China[31602174] ; National Natural Science Foundation of China[31672670] ; Natural Science Foundation of Hubei[2016CFB282] ; Key Project of Hubei Provincial Science and Technology Department[2015BBA226] ; Youth Talent Support Program of IHB[Y75E041201] ; China Agriculture Research System[CARS-45-09] ; Major Science and Technology Program for Water Pollution Control and Treatment[2017ZX07203001] ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ05] ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology[2016FBZ06]
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
WOS记录号WOS:000459528400100
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Natural Science Foundation of Hubei ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Key Project of Hubei Provincial Science and Technology Department ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; Youth Talent Support Program of IHB ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Major Science and Technology Program for Water Pollution Control and Treatment ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology ; Fund Project of the State Key Laboratory of Freshwater Ecology and Biotechnology
源URL[http://ir.ihb.ac.cn/handle/342005/28065]  
专题水生生物研究所_淡水生态学研究中心
通讯作者Liu, Haokun
作者单位1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Freshwater Aquaculture Collaborat Innovat Ctr Hub, Wuhan 430070, Hubei, Peoples R China
4.CJ Cheiljedang Ctr, CJ Cheiljedang BIO Tech Mkt Team, Seoul 04560, South Korea
推荐引用方式
GB/T 7714		 Zhang, Peiyu,Fu, Lele,Liu, Haokun,et al. Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection[J]. FISH & SHELLFISH IMMUNOLOGY,2019,86:913-921.
APA Zhang, Peiyu.,Fu, Lele.,Liu, Haokun.,Huda, Noor-Ul.,Zhu, Xiaoming.,...&Xie, Shouqi.(2019).Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection.FISH & SHELLFISH IMMUNOLOGY,86,913-921.
MLA Zhang, Peiyu,et al."Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS III), and its challenge against Aeromonas hydrophila infection".FISH & SHELLFISH IMMUNOLOGY 86(2019):913-921.

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来源：水生生物研究所

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