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Secretogranin-II plays a critical role in zebrafish neurovascular modeling

文献类型：期刊论文

作者Tao, Binbin1,2; Hu, Hongling1,2; Mitchell, Kimberly3; Chen, Ji1; Jia, Haibo4; Zhu, Zuoyan1; Trudeau, Vance L.3; Hu, Wei1
刊名JOURNAL OF MOLECULAR CELL BIOLOGY
出版日期2018-10-01
卷号10期号:5页码:388-401
关键词Secretogranin-II secretoneurin TALENs neurovascular zebrafish
ISSN号1674-2788
DOI10.1093/jmcb/mjy027
通讯作者Trudeau, Vance L.(trudeauv@uottawa.ca) ; Hu, Wei(huwei@ihb.ac.cn)
英文摘要Secretoneurin (SN) is a neuropeptide derived from specific proteolytic processing of the precursor secretogranin II (SgII). In zebrafish and other teleosts, there are two paralogs named sgIIa and sgIIb. Our results showed that neurons expressing sgIIb were aligned with central arteries in the hindbrain, demonstrating a close neurovascular association. Both sgIIb(-/-) and sgIIa(-/-)/sgIIb(-/-) mutant embryos were defective in hindbrain central artery development due to impairment of migration and proliferation of central artery cells. Further study revealed that sgIIb is non-cell autonomous and required for central artery development. Hindbrain arterial and venous network identities were not affected in sgIIb(-/-) mutant embryos, and the mRNA levels of Notch and VEGF pathway-related genes were not altered. However, the activation of MAPK and PI3K/AKT pathways was inhibited in sgIIb(-/-) mutant embryos. Reactivation of MAPK or PI3K/AKT in endothelial cells could partially rescue the central artery developmental defects in the sgIIb mutants. This study provides the first in vivo evidence that sgIIb plays a critical role in neurovascular modeling of the hindbrain. Targeting the SgII system may, therefore, represent a new avenue for the treatment of vascular defects in the central nervous system.
WOS关键词BLOOD-VESSELS ; SECRETONEURIN ; ANGIOGENESIS ; NEUROPEPTIDE ; MECHANISMS ; CANCER ; NOTCH ; RAT ; GRIDLOCK ; RECEPTOR
资助项目National Natural Science Foundation of China[31325026] ; National Natural Science Foundation of China[31721005] ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000455315700003
出版者OXFORD UNIV PRESS
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; Natural Sciences and Engineering Research Council of Canada ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program ; University of Ottawa International Research Acceleration Program
源URL[http://ir.ihb.ac.cn/handle/342005/28699]  
专题水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
通讯作者Trudeau, Vance L.; Hu, Wei
作者单位1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
3.Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada
4.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Mol Biophys, Wuhan 430074, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Tao, Binbin,Hu, Hongling,Mitchell, Kimberly,et al. Secretogranin-II plays a critical role in zebrafish neurovascular modeling[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2018,10(5):388-401.
APA Tao, Binbin.,Hu, Hongling.,Mitchell, Kimberly.,Chen, Ji.,Jia, Haibo.,...&Hu, Wei.(2018).Secretogranin-II plays a critical role in zebrafish neurovascular modeling.JOURNAL OF MOLECULAR CELL BIOLOGY,10(5),388-401.
MLA Tao, Binbin,et al."Secretogranin-II plays a critical role in zebrafish neurovascular modeling".JOURNAL OF MOLECULAR CELL BIOLOGY 10.5(2018):388-401.

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来源：水生生物研究所

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