A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish (Pelteobagrus fulvidraco)
文献类型:期刊论文
作者 | Dan, Cheng1; Lin, Qiaohong1; Gong, Gaorui1; Yang, Tianyi1; Xiong, Shuting1; Xiong, Yang1; Huang, Peipei2; Gui, Jian-Fang1,2; Mei, Jie1 |
刊名 | SCIENCE BULLETIN |
出版日期 | 2018-11-15 |
卷号 | 63期号:21页码:1420-1430 |
ISSN号 | 2095-9273 |
关键词 | Sex differentiation Yellow catfish Pfpdz1 Sex reversal |
DOI | 10.1016/j.scib.2018.08.012 |
通讯作者 | Gui, Jian-Fang(jfgui@ihb.ac.cn) ; Mei, Jie(jmei@mail.hzau.edu.cn) |
英文摘要 | The sex-determining genes are found to be variable among different fish species. Yellow catfish (Pelteobagrus fulvidraco) is an important aquaculture fish species in China with XX/XY sex-determining type. Recently, YY super-male yellow catfish has been successfully produced by combining hormonal-induced sex reversal method with sex chromosome-linked markers. Here, we identified a novel PDZ domain-containing gene in yellow catfish designated as pfpdz1, in whose intron the sex-linked marker was located. The coding sequence of pfpdz1 in Y chromosome was identical to that in X chromosome except a missense SNP (A/T) that changes an amino acid (E8V) in the N-terminal region. Pfpdz1 displayed male-specific expression during sex differentiation. Overexpression of pfpdz1 using additive transgenesis induces XX ovary to differentiate into testis-like tissue, while the targeted inactivation of pfpdz1 in Y chromosome using CRISPR/Cas9-mediated mutagenesis triggers ovarian differentiation. Furthermore, we demonstrated that pfpdz1 initiates testicular differentiation through upregulating expression of amh, dmrt1 and sox9a1, as well as downregulating expression of cyp19a1, foxl2 and wnt4. Our data provide functional evidence that pfpdz1 is significant for male differentiation and maintenance in yellow catfish. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
WOS关键词 | DMRT1 ; MARKERS ; TILAPIA ; CHROMOSOME ; REVERSAL ; IDENTIFICATION ; EFFICIENT ; ESTROGEN ; MEDAKA ; ROLES |
资助项目 | National Natural Science Foundation of China[31672635] ; China Agricultural Research System[CARS-46] |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | SCIENCE PRESS |
WOS记录号 | WOS:000451636900007 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System ; China Agricultural Research System |
源URL | [http://ir.ihb.ac.cn/handle/342005/28999] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Gui, Jian-Fang; Mei, Jie |
作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Dan, Cheng,Lin, Qiaohong,Gong, Gaorui,et al. A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish (Pelteobagrus fulvidraco)[J]. SCIENCE BULLETIN,2018,63(21):1420-1430. |
APA | Dan, Cheng.,Lin, Qiaohong.,Gong, Gaorui.,Yang, Tianyi.,Xiong, Shuting.,...&Mei, Jie.(2018).A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish (Pelteobagrus fulvidraco).SCIENCE BULLETIN,63(21),1420-1430. |
MLA | Dan, Cheng,et al."A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish (Pelteobagrus fulvidraco)".SCIENCE BULLETIN 63.21(2018):1420-1430. |
入库方式: OAI收割
来源:水生生物研究所
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