Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification
文献类型：期刊论文
| 作者 | Zhang, Weicheng1,2; Huang, Jiaolong2,3; Liang, Lei2,3; Yao, Lunguang1; Fang, Tao2,3 |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2019 |
| 卷号 | 214页码:754-763 |
| 关键词 | Dual impact Dissolved organic matter Cytotoxicity PVP-Ag NPs Escherichia coli |
| ISSN号 | 0045-6535 |
| DOI | 10.1016/j.chemosphere.2018.09.179 |
| 通讯作者 | Fang, Tao(fangt@ihb.ac.cn) |
| 英文摘要 | Cytotoxicity of silver nanoparticles (Ag NPs) is attributed to silver internalization, which can be depressed by dissolved organic matter (DOM) to form Ag-DOM. Ag-DOM are bioavailable and then silver internalization could be increased. Herein, 3 and 48-h Escherichia coli viability bioassays were employed to evaluate effect of fulvic acid and humic acid (10 mg L-1) on cytotoxicity of 30 and 100 nm PVP-Ag NPs. Moreover, zebrafish embryos were used as reference model to understand silver internalization routes. Ag ions or Ag-DOM internalization varied in routes to Escherichia coli and zebrafish embryos. Cytotoxicity mechanisms of PVP-Ag NPs are dynamic. In 3-h bioassays, cytotoxicity of PVP-Ag NPs mainly involves Ag particle-related toxicity. DOM significantly mitigated cytotoxicity of PVP-Ag NPs (p < 0.05) through adhering on surface of PVP-Ag NPs. Ag ions or Ag-DOM were hardly internalized into Escherichia coli cells during 3-h exposures duration. In 48-h bioassays, cytotoxicity of PVP-Ag NPs is dependent on Ag ion related and particle-related toxicity. Silver was internalized into Escherichia coli via Ag-DOM consumption as an indirect route. Thus, DOM promoted silver internalization into Escherichia coli but not into zebrafish embryos, significantly intensifying cytotoxicity (p < 0.05). The results suggested DOM has a dual impact on cytotoxicity of PVP-Ag NPs: mitigation and intensification. For risk assessment, it should be considered that cytotoxicity mechanisms of PVP-Ag NPs are dynamic and threats can be intensified by DOM during prolonged exposure. (C) 2018 Elsevier Ltd. All rights reserved. |
| WOS关键词 | NANO-SPECIFIC TOXICITY ; SILVER NANOPARTICLES ; ANTIBACTERIAL ACTIVITY ; ZNO NANOPARTICLES ; HUMIC-ACID ; PARTICLE ; AGGREGATION ; DISSOLUTION ; STABILITY ; ION |
| 资助项目 | National Natural Science Foundation of China[21477159] ; Scientific Research and Service Platform Fund of Henan Province[2016151] ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province[17454] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000449891300082 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; Scientific Research and Service Platform Fund of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province ; fund of the scientific and technological innovation team of water ecological security for the Water Source Region of Mid-line of the South-to-North Diversion Project of Henan Province |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/29015]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 通讯作者 | Fang, Tao |
| 作者单位 | 1.Nanyang Normal Univ, Coll Agr Engn, Collaborat Innovat Ctr Water Secur Water Source R, South To North Div Project Henan Prov, Nanyang 473061, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weicheng,Huang, Jiaolong,Liang, Lei,et al. Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification[J]. CHEMOSPHERE,2019,214:754-763. |
| APA | Zhang, Weicheng,Huang, Jiaolong,Liang, Lei,Yao, Lunguang,&Fang, Tao.(2019).Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification.CHEMOSPHERE,214,754-763. |
| MLA | Zhang, Weicheng,et al."Dual impact of dissolved organic matter on cytotoxicity of PVP-Ag NPs to Escherichia coli: Mitigation and intensification".CHEMOSPHERE 214(2019):754-763. |
入库方式： OAI收割
来源：水生生物研究所
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