An 8-week growth trial was conducted to investigate the effects of dietary fish meal replacement with a vegetable mixture of soybean meal and rapeseed meal (1:1) on growth of juvenile red swamp crayfish. Nine isonitrogenous diets were designed: V0, V34, V50, V65, V73 and V81 with six levels of vegetable proteins, and VA48, VA63 and VA78 by further adding crystalline lysine and methionine into V50, V65 and V81. Compared with V0, V34 significantly improved the specific growth rate (SGR), while V65, V73, V81 and VA78 depressed the SGR (p<.05). Feeding rate showed a decreasing trend as dietary vegetable protein level increased (p<.05), except that in VA48 group. Significantly lower FCR and higher PER were observed in V34 group, whereas all vegetable protein diets depressed the feed utilization of crayfish (p<.05). Crayfish fed with diets containing vegetable proteins showed significantly lower hepatosomatic indices and higher condition factors than the control (p<.05). Muscle lipid content was significantly (p<.05) lowered in V81 group, but not in VA78 group. The results suggested that 338 g/kg vegetable protein improved growth performance of crayfish. Excessive vegetable protein depressed the growth of crayfish, which could be prevented by lysine and methionine supplementation except for the all vegetable protein diets.