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Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV

文献类型：期刊论文

作者Cheng, Yong1,2,3; Schorey, Jeffrey S.1,2,3; Zhang, Cheng-Cai5; Tan, Xuejuan1,4
刊名CURRENT PHARMACEUTICAL DESIGN
出版日期2017
卷号23期号:29页码:4369-4389
关键词Protein kinase inhibitors antimicrobial drugs infectious diseases tuberculosis malaria AIDS
ISSN号1381-6128
DOI10.2174/1381612823666170612122429
通讯作者Cheng, Yong(ycheng5@nd.edu)
英文摘要Infectious diseases that are caused by pathogenic microbes such as bacteria, viruses, parasites or fungi remain the top major cause of death across the world, particularly in low income countries, and may be transmitted from person to person, or from insects or animals. In general, infectious diseases may be treated with antimicrobial agents including antibiotics, antiviral, antifungal or antiparasitic medications. The therapeutic application of antimicrobial drugs in the 20th century substantially contributed to the global control of infectious diseases worldwide. However, pathogenic microbes have evolved various mechanisms to render the antimicrobial drugs less effective. This has resulted in an increasing number of people infected with pathogenic microbes that are resistant to antimicrobial drugs, and in some cases leading to untreatable infections. Therefore, new antimicrobial drugs are urgently needed to prevent possible recurrence and emergence of previously treatable infectious diseases. In the past decades, protein kinase inhibitors have become an attractive area in the development of novel antimicrobial drugs. In the current review, we will describe the recent efforts in the development of microbial and host protein kinase-targeting inhibitors as potential antimicrobial drugs against HIV, tuberculosis and malaria.
WOS关键词PARASITE PLASMODIUM-FALCIPARUM ; CYCLIN-DEPENDENT KINASES ; BRUTONS TYROSINE KINASE ; YEAST SCHIZOSACCHAROMYCES-POMBE ; 2-COMPONENT REGULATORY SYSTEM ; GLYCOGEN-SYNTHASE KINASE-3 ; SIGNAL-TRANSDUCTION SYSTEM ; HOST-DIRECTED THERAPIES ; CELL-DIVISION CYCLE ; DOUBLE-STRANDED-RNA
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000415378600013
出版者BENTHAM SCIENCE PUBL LTD
源URL[http://ir.ihb.ac.cn/handle/342005/30741]  
专题水生生物研究所_藻类生物学及应用研究中心_期刊论文
通讯作者Cheng, Yong
作者单位1.Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA
2.Univ Notre Dame, Ctr Rare & Neglected Dis, Notre Dame, IN 46556 USA
3.Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA
4.Univ Notre Dame, Harper Canc Res Inst, Notre Dame, IN 46556 USA
5.Chinese Acad Sci, Key Lab Algal Biol, Inst Hydrobiol, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Cheng, Yong,Schorey, Jeffrey S.,Zhang, Cheng-Cai,et al. Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV[J]. CURRENT PHARMACEUTICAL DESIGN,2017,23(29):4369-4389.
APA Cheng, Yong,Schorey, Jeffrey S.,Zhang, Cheng-Cai,&Tan, Xuejuan.(2017).Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV.CURRENT PHARMACEUTICAL DESIGN,23(29),4369-4389.
MLA Cheng, Yong,et al."Protein Kinase Inhibitors as Potential Antimicrobial Drugs Against Tuberculosis, Malaria and HIV".CURRENT PHARMACEUTICAL DESIGN 23.29(2017):4369-4389.

入库方式： OAI收割

来源：水生生物研究所

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