Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia
文献类型:期刊论文
作者 | Da Fonte, Dillon F.1; Martyniuk, Christopher J.2,3; Xing, Lei1,5; Pelin, Adrian1; Corradi, Nicolas1; Hu, Wei4; Trudeau, Vance L.1 |
刊名 | SCIENTIFIC REPORTS |
出版日期 | 2017-11-02 |
卷号 | 7期号:1页码:14 |
ISSN号 | 2045-2322 |
DOI | 10.1038/s41598-017-14930-8 |
英文摘要 | Radial glial cells (RGCs) are the most abundant macroglia in the teleost brain and have established roles in neurogenesis and neurosteroidogenesis; however, their transcriptome remains uncharacterized, which limits functional understanding of this important cell type. Using cultured goldfish RGCs, RNA sequencing and de novo transcriptome assembly were performed, generating the first reference transcriptome for fish RGCs with 17,620 unique genes identified. These data revealed that RGCs express a diverse repertoire of receptors and signaling molecules, suggesting that RGCs may respond to and synthesize an array of hormones, peptides, cytokines, and growth factors. Building upon neuroanatomical data and studies investigating direct neuronal regulation of RGC physiology, differential gene expression analysis was conducted to identify transcriptional networks that are responsive to the conserved secretogranin II-derived neuropeptide secretoneurin A (SNa). Pathway analysis of the transcriptome indicated that cellular processes related to the central nervous system (e.g., neurogenesis, synaptic plasticity, glial cell development) and immune functions (e.g., immune system activation, leukocyte function, macrophage response) were preferentially modulated by SNa. These data reveal an array of new functions that are proposed to be critical to neuronal-glial interactions through the mediator SNa. |
WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; II CHROMOGRANIN-C ; ADULT ZEBRAFISH ; TELEOST FISH ; NEURAL PROGENITORS ; NEUROPEPTIDE SECRETONEURIN ; NEURONAL REGENERATION ; ALZHEIMERS-DISEASE ; ESTROGEN-RECEPTORS ; CELL-MIGRATION |
资助项目 | NSERC ; CGSM ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000414261500047 |
资助机构 | NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; NSERC ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; CGSM ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; Michael Smith Foreign Study Award ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; University of Ottawa Research Chair in Neuroendocrinology ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship ; Ontario Trillium Schoralship |
源URL | [http://ir.ihb.ac.cn/handle/342005/30769] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Trudeau, Vance L. |
作者单位 | 1.Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada 2.Univ Florida, Coll Vet Med, Dept Physiol Sci, Gainesville, FL 32611 USA 3.Univ Florida, Coll Vet Med, Interdisciplinary Program Biomed Sci Neurosci, Genet Inst,Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 5.Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany |
推荐引用方式 GB/T 7714 | Da Fonte, Dillon F.,Martyniuk, Christopher J.,Xing, Lei,et al. Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia[J]. SCIENTIFIC REPORTS,2017,7(1):14. |
APA | Da Fonte, Dillon F..,Martyniuk, Christopher J..,Xing, Lei.,Pelin, Adrian.,Corradi, Nicolas.,...&Trudeau, Vance L..(2017).Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia.SCIENTIFIC REPORTS,7(1),14. |
MLA | Da Fonte, Dillon F.,et al."Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia".SCIENTIFIC REPORTS 7.1(2017):14. |
入库方式: OAI收割
来源:水生生物研究所
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