Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription
文献类型:期刊论文
作者 | Wu, Min1,2; Dan, Cheng1; Gui, Jian-Fang1,2,3; Zhang, Yi-Bing1,2,3,4 |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
出版日期 | 2019-07-01 |
卷号 | 90期号:1页码:180-187 |
ISSN号 | 1050-4648 |
关键词 | finTRIM FTRCA1 RLR signaling IFN antiviral response Negative regulation |
DOI | 10.1016/j.fsi.2019.04.297 |
英文摘要 | In mammals and fish, emerging evidence highlights that TRIM family members play important roles in the interferon (IFN) antiviral immune response. Fish TRIM family has undergone an unprecedented expansion leading to generation of finTRIM subfamily, which is exclusively specific to fish. Our recent results have shown that FTRCA1 (finTRIM C. auratus 1) is likely a fish species-specific finTRIM member in crucian carp C. auratus and acts as a negative modulator to downregulate fish IFN response by autophage-lysosomal degradation of protein kinase TBK1. In the present study, we found that FTRCA1 also impedes the activation of crucian carp IFN promoter by IRF7 but not by IRF3. Mechanistically, FTRCA1 attenuates IRF7 transcription levels likely due to enhanced decay of IRF7 mRNA, leading to reduced IRF7 protein levels and subsequently reduced fish IFN expression. E3 ligase activity is required for FTRCA1 to negatively regulate IRF7-mediated IFN response, because ligase-inactive mutants and the RING-deleted mutant of FTRCA1 lose the ability to block the activation of crucian carp IFN promoter by IRF7. These results together indicate that FTRCA1 is a multifaceted modulator to target different signaling factors for shaping fish IFN response in crucian carp. |
WOS关键词 | ANTIVIRAL RESPONSE ; RIG-I ; ZEBRAFISH IRF1 ; PROTEINS ; FAMILY ; ROLES ; ACTIVATION ; EXPRESSION ; IFN-PHI-1 ; REVEALS |
资助项目 | National Key R&D Program of China[2018YFD0900302] ; National Natural Science Foundation of China[31572646] ; National Natural Science Foundation of China[31772875] ; Freshwater Ecology and Biotechnology Laboratory[2019FBZ04] |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000471085000020 |
资助机构 | National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; Freshwater Ecology and Biotechnology Laboratory ; 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源URL | [http://ir.ihb.ac.cn/handle/342005/31335] |
专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
通讯作者 | Zhang, Yi-Bing |
作者单位 | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 10049, Peoples R China 3.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Hubei, Peoples R China 4.Chinese Acad Sci, Key Lab Aquaculture Dis Control, Minist Agr, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Min,Dan, Cheng,Gui, Jian-Fang,et al. Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription[J]. FISH & SHELLFISH IMMUNOLOGY,2019,90(1):180-187. |
APA | Wu, Min,Dan, Cheng,Gui, Jian-Fang,&Zhang, Yi-Bing.(2019).Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription.FISH & SHELLFISH IMMUNOLOGY,90(1),180-187. |
MLA | Wu, Min,et al."Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription".FISH & SHELLFISH IMMUNOLOGY 90.1(2019):180-187. |
入库方式: OAI收割
来源:水生生物研究所
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