Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes
文献类型：期刊论文
| 作者 | Zhen, Yan-Feng1; Liu, Xing-Yu2; Li, Yu-Kai1; Fang, Hui1; Cassidy, Ryan M.3; Zhang, Xiang Yang4
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| 刊名 | PSYCHOSOMATIC MEDICINE
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| 出版日期 | 2019-07-01 |
| 卷号 | 81期号:6页码:488-494 |
| ISSN号 | 0033-3174 |
| 关键词 | association BDNF cognition serum sex difference |
| DOI | 10.1097/PSY.0000000000000709 |
| 通讯作者 | Fang, Hui(jane791115@126.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn) |
| 英文摘要 | Objective Although a reduction in brain-derived neurotrophic factor (BDNF) has been implicated as a cause of cognitive impairment in type 2 diabetes mellitus (T2DM), the role of sex in moderating this effect has not been explored. Methods We compared the difference in serum BDNF and performance on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) between 96 men and 134 women with T2DM. We compared this with the difference in serum BDNF and performance in the control group (104 men, 144 women). Results Patients with T2DM performed worse on most RBANS indices (eta(2) = 0.372, all p < .05); within T2DM patients, men performed worse than women on the delayed memory score (74.1 (12.1) versus 79.9 (11.5), p = .002) and on the total score (71.4 (11.5) versus 76.5 (10.8), p = .025). Serum BDNF was lower in patients with T2DM versus controls (7.5 (2.7) ng/ml versus 11.5 (2.7) ng/ml, p < .001), and in men compared with women (6.9 (2.4) versus 7.9 (2.8), p = .024). Serum BDNF levels positively correlated with delayed memory score in patients with T2DM (beta = 0.19, p = .007). However, this association was only observed in women, not in men (p(interaction) = 0.04). Among healthy controls, no sex differences were noted in either RBANS or BDNF levels (eta(2) = 0.04, Cohen's d < 0.163, all p > .05). Conclusions Our results show sex differences in poorer cognitive performance, lower BDNF concentration, and their relationship in T2DM patients, suggesting that female sex may be a protective factor for cognitive decline in T2DM patients. However, the findings should be regarded as preliminary because of the cross-sectional design and chronicity of the diabetes. |
| WOS关键词 | MIDDLE-AGED MEN ; SYNAPTIC-TRANSMISSION ; CIGARETTE-SMOKING ; HUMAN-MEMORY ; BDNF LEVELS ; DECLINE ; GENDER ; RISK ; COMPLICATIONS ; MODULATION |
| 资助项目 | National Natural Science Foundation of China[81371477] |
| WOS研究方向 | Psychiatry ; Psychology |
| 语种 | 英语 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| WOS记录号 | WOS:000475406800001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/29518]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Fang, Hui; Zhang, Xiang Yang |
| 作者单位 | 1.Tangshan Gongren Hosp, Dept Endocrinol, 27 Wenhua Rd, Tangshan, Hebei, Peoples R China 2.Tangshan Gongren Hosp, Dept Neurosurg, Tangshan, Peoples R China 3.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhen, Yan-Feng,Liu, Xing-Yu,Li, Yu-Kai,et al. Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes[J]. PSYCHOSOMATIC MEDICINE,2019,81(6):488-494. |
| APA | Zhen, Yan-Feng,Liu, Xing-Yu,Li, Yu-Kai,Fang, Hui,Cassidy, Ryan M.,&Zhang, Xiang Yang.(2019).Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes.PSYCHOSOMATIC MEDICINE,81(6),488-494. |
| MLA | Zhen, Yan-Feng,et al."Association of Brain-Derived Neurotrophic Factor With Cognitive Function: An Investigation of Sex Differences in Patients With Type 2 Diabetes".PSYCHOSOMATIC MEDICINE 81.6(2019):488-494. |
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来源：心理研究所
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