Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432
文献类型：期刊论文
| 作者 | Li, Zhe1,2; Ma, Ni1,2; Zhao, Pei-Ji1,2 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2019-06-18 |
| 卷号 | 33期号:12页码:1794-1797 |
| 关键词 | Huperzia serrata endophytic fungus Chaetomium sp YMF 432 metabolites acetylcholinesterase inhibitory |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2018.1434648 |
| 通讯作者 | Zhao, Pei-Ji(pjzhao@ynu.edu.cn) |
| 英文摘要 | An endophytic fungus, Chaetomium sp. YMF432, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. From the extracts of fermentation solid of strain YMF 432, eight compounds including 1-O-methylemodin (1), 5-methoxy-2-methyl-3-tricosyl-1,4-benzoquinone (2), 4,8-dihydroxy-1-tetralone (3), (3 beta,5 alpha,6 alpha, 22E)-3-hydroxy-5,6-epoxy-7-one-8(14),22-dien-ergosta (4), ergosta-4,6,8(14),22-tetraen-3-one (5), beta-sitostenone (6), beta-sitosterol (7) and (22E,24R)-ergosta-5,7,22 -trien-3 beta-ol (8) were obtained. Their structures were elucidated on the basis of their spectroscopic data. These compounds were evaluated for acetylcholinesterase inhibitory activities in vitro. Compounds 1, 2, and 4 showed moderate acetylcholinesterase inhibitory activities (IC50 from 37.7 +/- 1.5 to 370.0 +/- 2.9 mu M). [GRAPHICS] . |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000469988800020 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67392]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhao, Pei-Ji |
| 作者单位 | 1.Yunnan Univ, State Key Lab Conservat & Utilizat Bio Resources, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhe,Ma, Ni,Zhao, Pei-Ji. Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432[J]. NATURAL PRODUCT RESEARCH,2019,33(12):1794-1797. |
| APA | Li, Zhe,Ma, Ni,&Zhao, Pei-Ji.(2019).Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432.NATURAL PRODUCT RESEARCH,33(12),1794-1797. |
| MLA | Li, Zhe,et al."Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432".NATURAL PRODUCT RESEARCH 33.12(2019):1794-1797. |
入库方式： OAI收割
来源：昆明植物研究所
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