Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii
文献类型：期刊论文
| 作者 | Zhan, Rui1; Hu, You-Tian2; Shao, Li-Dong3; Qin, Xu-Jie4 ; Kuang, Fang1; Du, Shou-Zhen1; Wu, Fang2; Chen, Ye-Gao1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2019-05-17 |
| 卷号 | 21期号:10页码:3678-3681 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.9b01125 |
| 通讯作者 | Wu, Fang(fang.wu@sjtu.edu.cn) ; Chen, Ye-Gao(ygchen48@126.com) |
| 英文摘要 | Horisfieldones A (1) and B (2), two dimeric diarylpropanes featuring an unprecedentedly aromatic ring-contracted framework, were isolated from Horsfieldia kingii. Their structures and absolute configurations were determined by the inspection of extensive spectroscopic data and electronic circular dichroism calculations. Molecular modeling analysis, in vitro enzyme-based bioassays, and structure-activity relationship analysis of these isolates revealed that (+)-1 (IC50 = 35.1 +/- 3.9 mu M, SI > 11.4) could present a new class of human DOPA decarboxylase inhibitor. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000468696100044 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67525]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Wu, Fang; Chen, Ye-Gao |
| 作者单位 | 1.Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, Shanghai 200240, Peoples R China 3.Yunnan Univ Chinese Med, Dept Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhan, Rui,Hu, You-Tian,Shao, Li-Dong,et al. Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii[J]. ORGANIC LETTERS,2019,21(10):3678-3681. |
| APA | Zhan, Rui.,Hu, You-Tian.,Shao, Li-Dong.,Qin, Xu-Jie.,Kuang, Fang.,...&Chen, Ye-Gao.(2019).Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii.ORGANIC LETTERS,21(10),3678-3681. |
| MLA | Zhan, Rui,et al."Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingii".ORGANIC LETTERS 21.10(2019):3678-3681. |
入库方式： OAI收割
来源：昆明植物研究所
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