中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.

文献类型:期刊论文

作者Zhang, Han1,2; Zhu, Hong-Tao1; Wang, Dong1; Yang, Chong-Ren1; Zhang, Ying-Jun1,3
刊名NATURAL PRODUCT RESEARCH
出版日期2019-05-03
卷号33期号:9页码:1284-1291
关键词Aspergillus penicilliodes Speg sphingofungins G and H cytotoxicity
ISSN号1478-6419
DOI10.1080/14786419.2018.1470627
通讯作者Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
英文摘要Two new sphingofungins G (1) and H (2) with a five-membered lactone ring were identified from the solid-state fermentation of Aspergillus penicilliodes Speg., a dominant microorganism isolated previously from the post-fermentation of ripe Pu-er tea, together with six known metabolites. Their structures were elucidated by extensive spectroscopic methods. All of them were isolated from the mycelia culture of A. penicilliodes for the first time. The known compound, trypacidin, exhibited potent cytotoxities against five human cancer cell lines, e.g. myeloid leukemia HL-60, lung cancer A-549, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480, with IC50 values of 0.55, 11.45, 10.95, 3.58, and 3.49 mu M, resp., while cisplatin as the positive control, with IC50 values of 8.63, 24.15, 21.99, 27.29, and 23.61 mu M, resp. [GRAPHICS] .
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000468074400008
源URL[http://ir.kib.ac.cn/handle/151853/67531]  
专题昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zhang, Ying-Jun
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Han,Zhu, Hong-Tao,Wang, Dong,et al. Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.[J]. NATURAL PRODUCT RESEARCH,2019,33(9):1284-1291.
APA Zhang, Han,Zhu, Hong-Tao,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2019).Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg..NATURAL PRODUCT RESEARCH,33(9),1284-1291.
MLA Zhang, Han,et al."Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.".NATURAL PRODUCT RESEARCH 33.9(2019):1284-1291.

入库方式: OAI收割

来源:昆明植物研究所

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