Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.
文献类型：期刊论文
| 作者 | Zhang, Han1,2; Zhu, Hong-Tao1; Wang, Dong1 ; Yang, Chong-Ren1; Zhang, Ying-Jun1,3
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| 刊名 | NATURAL PRODUCT RESEARCH
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| 出版日期 | 2019-05-03 |
| 卷号 | 33期号:9页码:1284-1291 |
| 关键词 | Aspergillus penicilliodes Speg sphingofungins G and H cytotoxicity |
| ISSN号 | 1478-6419 |
| DOI | 10.1080/14786419.2018.1470627 |
| 通讯作者 | Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn) |
| 英文摘要 | Two new sphingofungins G (1) and H (2) with a five-membered lactone ring were identified from the solid-state fermentation of Aspergillus penicilliodes Speg., a dominant microorganism isolated previously from the post-fermentation of ripe Pu-er tea, together with six known metabolites. Their structures were elucidated by extensive spectroscopic methods. All of them were isolated from the mycelia culture of A. penicilliodes for the first time. The known compound, trypacidin, exhibited potent cytotoxities against five human cancer cell lines, e.g. myeloid leukemia HL-60, lung cancer A-549, hepatocellular carcinoma SMMC7721, breast cancer MCF-7, and colon cancer SW480, with IC50 values of 0.55, 11.45, 10.95, 3.58, and 3.49 mu M, resp., while cisplatin as the positive control, with IC50 values of 8.63, 24.15, 21.99, 27.29, and 23.61 mu M, resp. [GRAPHICS] . |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000468074400008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67531]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhang, Ying-Jun |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Han,Zhu, Hong-Tao,Wang, Dong,et al. Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.[J]. NATURAL PRODUCT RESEARCH,2019,33(9):1284-1291. |
| APA | Zhang, Han,Zhu, Hong-Tao,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2019).Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg..NATURAL PRODUCT RESEARCH,33(9),1284-1291. |
| MLA | Zhang, Han,et al."Sphingofungins G and H: new five-membered lactones from Aspergillus penicilliodes Speg.".NATURAL PRODUCT RESEARCH 33.9(2019):1284-1291. |
入库方式： OAI收割
来源：昆明植物研究所
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