The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans
文献类型：期刊论文
| 作者 | Wan, Qin-Li1; Yang, Zhong-Lin2,3; Zhou, Xiao-Gang1; Ding, Ai-Jun1; Pu, Yuan-Zhu1; Luo, Huai-Rong1,2 ; Wu, Gui-Sheng1
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| 刊名 | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
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| 出版日期 | 2019 |
| 页码 | 14 |
| ISSN号 | 1942-0900 |
| DOI | 10.1155/2019/5768953 |
| 通讯作者 | Wu, Gui-Sheng(wgs@swmu.edu.cn) |
| 英文摘要 | Aging is a complex life process, and a unified view is that metabolism plays key roles in all biological processes. Here, we determined the lipidomic profile of Caenorhabditis elegans (C. elegans) using ultraperformance liquid chromatography high-resolution mass spectrometry (UPLC-HRMS). Using a nontargeted approach, we detected approximately 3000 species. Analysis of the lipid metabolic profiles at young adult and ten-day-old ages among wild-type N2, glp-1 defective mutant, and double mutant daf-16;glp-1 uncovered significant age-related differences in the total amount of phosphatidylcholines (PC), sphingomyelins (SM), ceramides (Cer), diglycerides (DG), and triglycerides (TG). In addition, the age-associated lipid profiles were characterized by ratio of polyunsaturated (PUFA) over monounsaturated (MUFA) lipid species. Lipid metabolism modulation plays an important role in reproduction-regulated aging; to identify the variations of lipid metabolites during germ line loss-induced longevity, we investigated the lipidomic profiles of long-lived glp-1/notch receptor mutants, which have reproductive deficiency when grown at nonpermissive temperature. The results showed that there was some age-related lipid variation, including TG 40:2, TG 40:1, and TG 41:1, which contributed to the long-life phenotype. The longevity of glp-1 mutant was daf-16-dependent; the lipidome analysis of daf-16;glp-1 double mutant revealed that the changes of some metabolites in the glp-1 mutant were daf-16-dependent, while other metabolites displayed more complex epistatic patterns. We first conducted a comprehensive lipidome analysis to provide novel insights into the relationships between longevity and lipid metabolism regulated by germ line signals in C. elegans. |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000468566800001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67553]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Wu, Gui-Sheng |
| 作者单位 | 1.Southwest Med Univ, Sch Pharm, Dept Pharmacol, Key Lab Aging & Regenerat Med, Luzhou 646000, Sichuan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Qin-Li,Yang, Zhong-Lin,Zhou, Xiao-Gang,et al. The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2019:14. |
| APA | Wan, Qin-Li.,Yang, Zhong-Lin.,Zhou, Xiao-Gang.,Ding, Ai-Jun.,Pu, Yuan-Zhu.,...&Wu, Gui-Sheng.(2019).The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,14. |
| MLA | Wan, Qin-Li,et al."The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019):14. |
入库方式： OAI收割
来源：昆明植物研究所
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