Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis
文献类型：期刊论文
| 作者 | Guo, Yi1; Tong, Qingyi1; Zhang, Na1; Duan, Xueyan1; Cao, Yunfang1; Zhu, Hucheng1; Xie, Shuangshuang1; Yang, Jing2 ; Zhang, Jinwen3; Liu, Yanfei4
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2019-03-21 |
| 卷号 | 6期号:6页码:817-824 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/c8qo01268g |
| 通讯作者 | Xue, Yongbo(yongboxue@mail.hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn) |
| 英文摘要 | Spirohypolactones A (1) and B (2) and hyperhexanones C-E (3-5), five degraded cyclohexanone-monocyclic polyprenylated acylphloroglucinol (C-MPAP) derivatives were isolated from the stems and leaves of Hypericum perforatum. The structures of these compounds were established by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of naturally occurring C-MPAPs possessing 2-oxaspiro[4.5]decane spirocyclic skeletons. Compound 5 featured an unusual dodecahydro-4H-oxocino[4,3-g]benzofuran ring system. Notably, compounds 3 and 4 induce apoptosis in the acute myeloid leukemia cell lines NB4 and HL-60 by the activation of caspase-3, and degradation of PARP. The proposed biosynthetic pathways and biological activities are also discussed. |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000462670600015 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67689]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Xue, Yongbo; Zhang, Yonghui |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China 4.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp, Wuhan 430030, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yi,Tong, Qingyi,Zhang, Na,et al. Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(6):817-824. |
| APA | Guo, Yi.,Tong, Qingyi.,Zhang, Na.,Duan, Xueyan.,Cao, Yunfang.,...&Zhang, Yonghui.(2019).Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis.ORGANIC CHEMISTRY FRONTIERS,6(6),817-824. |
| MLA | Guo, Yi,et al."Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis".ORGANIC CHEMISTRY FRONTIERS 6.6(2019):817-824. |
入库方式： OAI收割
来源：昆明植物研究所
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