Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum
文献类型：期刊论文
| 作者 | Zhang, Dongdong1,2,3; Fu, Yao1,2,3; Yang, Jun1,2,3; Li, Xiao-Nian2,3; San, Myint Myint4; Oo, Thaung Naing4; Wang, Yuehu1,2,3 ; Yang, Xuefei1,2,3
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| 刊名 | MOLECULES
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| 出版日期 | 2019-06-02 |
| 卷号 | 24期号:12页码:23 |
| 关键词 | Glinus oppositifolius triterpenoids and triterpenoid saponins antifungal activity |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules24122206 |
| 通讯作者 | Wang, Yuehu(wangyuehu@mail.kib.ac.cn) ; Yang, Xuefei(xuefei@mail.kib.ac.cn) |
| 英文摘要 | Four new triterpenoids, 3 beta,12 beta,16 beta,21 beta,22-pentahydroxyhopane (1), 12 beta,16 beta,21 beta,22-tetrahydroxyhopan-3-one (2), 3-oxo-olean-12-ene-28,30-dioic acid (3), and 3 beta-hydroxyoleana-11,13(18)-diene-28,30-dioic acid 30-methyl ester (4); 21 new triterpenoid saponins, glinusopposides A-U (5-25); and 12 known compounds (26-37) were isolated from the whole plants of Glinus oppositifolius. The structures of the new compounds were elucidated based on the analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. All compounds from the plants were measured for antifungal activities against Microsporum gypseum and Trichophyton rubrum. Glinusopposide B (6), glinusopposide Q (21), glinusopposide T (24), and glinusopposide U (25) showed strong inhibitory activities against M. gypseum (MIC50 7.1, 6.7, 6.8, and 11.1 mu M, respectively) and T. rubrum (MIC50 14.3, 13.4, 11.9, and 13.0 mu M, respectively). For those active compounds with an oleanane skeleton, glycosylation (21-26) or oxidation (3) of 3-OH was helpful in increasing the activity; replacement of the 30-methyl group (29) by a carboxymethyl group (26) enhanced the activity; the presence of 11,13(18) double bonds (20) decreased the activity. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000473816900012 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67884]  |
| 专题 | 昆明植物研究所_资源植物与生物技术所级重点实验室 |
| 通讯作者 | Wang, Yuehu; Yang, Xuefei |
| 作者单位 | 1.Chinese Acad Sci, Southeast Asia Biodivers Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar 2.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Forest Res Inst, Yezin 05282, Nay Pyi Taw, Myanmar |
| 推荐引用方式 GB/T 7714 | Zhang, Dongdong,Fu, Yao,Yang, Jun,et al. Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum[J]. MOLECULES,2019,24(12):23. |
| APA | Zhang, Dongdong.,Fu, Yao.,Yang, Jun.,Li, Xiao-Nian.,San, Myint Myint.,...&Yang, Xuefei.(2019).Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum.MOLECULES,24(12),23. |
| MLA | Zhang, Dongdong,et al."Triterpenoids and Their Glycosides from Glinus Oppositifolius with Antifungal Activities against Microsporum Gypseum and Trichophyton Rubrum".MOLECULES 24.12(2019):23. |
入库方式： OAI收割
来源：昆明植物研究所
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