Hepatoprotective steroids from roots of Cynanchum otophyllum
文献类型：期刊论文
| 作者 | Dong, Jinrun1,2,3; Peng, Xingrong1,3; Lu, Shuangyang1,2,3; Zhou, Lin1,3; Qiu, Minghua1,3
|
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2019-07-01 |
| 卷号 | 136页码:7 |
| 关键词 | Cynanchum otophyllum Asclepiadaceae Steriods Anti-liver fibrosis activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2019.104171 |
| 通讯作者 | Qiu, Minghua(mhchiu@mail.kib.ac.cn) |
| 英文摘要 | Seven undescribed C21 steroids, namely cynanchin A-G, together with thirteen known analogues, were isolated from the roots of cynanchum otophyllum. Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as chemical methods. Meanwhile, all of isolates were tested for their anti-hepatic fibrosis activity. Among them, compounds 4-6, 10-12 and 14-17 showed moderate or significant inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-beta 1 (TGF-beta 1) in vitro. |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000474320500017 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/67951]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Qiu, Minghua |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,et al. Hepatoprotective steroids from roots of Cynanchum otophyllum[J]. FITOTERAPIA,2019,136:7. |
| APA | Dong, Jinrun,Peng, Xingrong,Lu, Shuangyang,Zhou, Lin,&Qiu, Minghua.(2019).Hepatoprotective steroids from roots of Cynanchum otophyllum.FITOTERAPIA,136,7. |
| MLA | Dong, Jinrun,et al."Hepatoprotective steroids from roots of Cynanchum otophyllum".FITOTERAPIA 136(2019):7. |
入库方式： OAI收割
来源：昆明植物研究所
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